Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Irf8 KO Male
M
12wk
strain name: B6N(Cg)-Irf8<tm1b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Irf8 KO Female
F
12wk
strain name: B6N(Cg)-Irf8<tm1b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Irf8 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Irf8 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Irf8 WT Male (Mean ± SD) | Irf8 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 70.22 ± 4.53 | 65.42 ± 5.21 | 0.0990 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 35.50 ± 5.26 | 36.44 ± 2.57 | 0.7381 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 35.17 ± 1.67 | 31.47 ± 1.98 | 0.0069* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 4.01 ± 1.12 | 7.97 ± 2.13 | 0.0019* |
| Body Weight (g) | 24.25 ± 2.38 | 22.52 ± 1.77 | 0.1664 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.351 ± 0.079 | 0.432 ± 0.069 | 0.1103 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 9.61 ± 2.05 | 4.46 ± 1.36 | <0.001* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 49.99 ± 4.41 | 53.58 ± 0.62 | 0.0690 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.38 ± 0.14 | 1.57 ± 0.14 | 0.0399* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 25.67 ± 3.65 | 27.06 ± 0.83 | 0.4573 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 50.01 ± 4.41 | 46.42 ± 0.62 | 0.0690 |
| Trabecular Number (Tb.N) (#/mm) | 2.07 ± 0.35 | 1.11 ± 0.42 | <0.001* |
| Trabecular Spacing (Tb.Sp) (µm) | 455.80 ± 92.28 | 1,071.41 ± 512.15 | 0.0083* |
| Trabecular Thickness (Tb.Th) (µm) | 46.31 ± 4.03 | 39.69 ± 3.72 | 0.0091* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 20.64 ± 2.54 | 34.15 ± 4.63 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 8.33 ± 1.51 | 14.94 ± 2.77 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 12.55 ± 1.45 | 17.63 ± 2.97 | 0.0030* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 75.85 ± 5.39 | 73.65 ± 11.20 | 0.6518 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 39.86 ± 4.43 | 45.65 ± 3.68 | 0.0464* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 60.14 ± 4.43 | 54.35 ± 3.68 | 0.0464* |