Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Mettl21c KO Male
M
12wk
B6N(Cg)-Mettl21c<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Mettl21c KO Female
F
12wk
B6N(Cg)-Mettl21c<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Mettl21c WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Mettl21c WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Mettl21c WT Male (Mean ± SD) | Mettl21c KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 55.34 ± 12.57 | 63.97 ± 7.91 | 0.1572 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 34.37 ± 7.19 | 23.60 ± 7.05 | 0.0234* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 23.16 ± 5.06 | 41.27 ± 9.99 | 0.0027* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 5.57 ± 1.46 | 1.76 ± 0.91 | <0.001* |
| Body Weight (g) | 24.37 ± 1.20 | 26.84 ± 2.23 | 0.0219* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.462 ± 0.064 | 0.222 ± 0.063 | <0.001* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.12 ± 0.74 | 13.16 ± 2.93 | 0.0183* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 59.75 ± 2.32 | 36.58 ± 10.46 | <0.001* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.41 ± 0.15 | 1.374 ± 0.081 | 0.5566 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 31.14 ± 1.56 | 17.39 ± 5.26 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 40.25 ± 2.32 | 63.42 ± 10.46 | <0.001* |
| Trabecular Number (Tb.N) (#/mm) | 2.21 ± 0.20 | 2.42 ± 0.53 | 0.3297 |
| Trabecular Spacing (Tb.Sp) (µm) | 411.49 ± 39.85 | 383.73 ± 87.41 | 0.4573 |
| Trabecular Thickness (Tb.Th) (µm) | 47.56 ± 4.11 | 53.72 ± 4.35 | 0.0163* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 25.17 ± 2.52 | 18.95 ± 3.70 | 0.0025* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 12.24 ± 1.39 | 4.96 ± 2.18 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 12.77 ± 2.31 | 14.36 ± 2.59 | 0.2681 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 76.26 ± 2.80 | 74.28 ± 3.75 | 0.2813 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 49.00 ± 4.64 | 25.14 ± 8.70 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.00 ± 4.64 | 74.86 ± 8.70 | <0.001* |