Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Ghsr KO Male
M
12wk
B6N(Cg)-Ghsr<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Ghsr KO Female
F
12wk
B6N(Cg)-Ghsr<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Ghsr WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Ghsr WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Ghsr WT Male (Mean ± SD) | Ghsr KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 49.79 ± 9.23 | 59.91 ± 7.85 | 0.0442* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 28.35 ± 6.74 | 31.27 ± 3.46 | 0.3528 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 22.73 ± 3.29 | 30.18 ± 7.79 | 0.0390* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.79 ± 1.30 | 4.49 ± 1.28 | 0.3664 |
| Body Weight (g) | 22.00 ± 3.26 | 20.46 ± 1.87 | 0.2983 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.40 ± 0.13 | 0.398 ± 0.081 | 0.9235 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 7.42 ± 2.88 | 9.59 ± 2.20 | 0.1487 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 54.90 ± 6.08 | 51.50 ± 7.05 | 0.3681 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.48 ± 0.30 | 1.47 ± 0.23 | 0.9658 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 26.97 ± 4.09 | 26.21 ± 3.59 | 0.7281 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 45.10 ± 6.08 | 48.50 ± 7.05 | 0.3681 |
| Trabecular Number (Tb.N) (#/mm) | 1.75 ± 0.51 | 2.07 ± 0.60 | 0.3237 |
| Trabecular Spacing (Tb.Sp) (µm) | 592.12 ± 198.27 | 491.34 ± 161.68 | 0.3314 |
| Trabecular Thickness (Tb.Th) (µm) | 43.14 ± 7.51 | 48.87 ± 2.29 | 0.0885 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 20.79 ± 1.70 | 25.55 ± 3.36 | 0.0076* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 9.16 ± 2.74 | 10.53 ± 1.99 | 0.3438 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 11.65 ± 1.59 | 15.75 ± 3.01 | 0.0121* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 78.38 ± 5.24 | 73.19 ± 8.60 | 0.2190 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 43.59 ± 10.80 | 40.40 ± 6.80 | 0.5513 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 56.41 ± 10.80 | 59.60 ± 6.80 | 0.5513 |