Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
R3hcc1l KO Male
M
12wk
B6N(Cg)-R3hcc1l<tm1b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
R3hcc1l KO Female
F
12wk
B6N(Cg)-R3hcc1l<tm1b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
R3hcc1l WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
R3hcc1l WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | R3hcc1l WT Male (Mean ± SD) | R3hcc1l KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 50.60 ± 5.88 | 22.68 ± 10.80 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.00 ± 4.87 | 14.78 ± 6.05 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 22.01 ± 3.66 | 9.77 ± 4.57 | <0.001* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.46 ± 0.48 | 1.76 ± 0.93 | 0.0073* |
| Body Weight (g) | 27.49 ± 2.14 | 24.68 ± 0.76 | 0.0055* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.366 ± 0.074 | 0.346 ± 0.046 | 0.5749 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.61 ± 1.37 | 16.37 ± 1.81 | 0.0061* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.60 ± 5.31 | 60.51 ± 3.03 | 0.1602 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.26 ± 0.16 | 1.33 ± 0.14 | 0.4103 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 28.20 ± 3.69 | 26.68 ± 1.76 | 0.3531 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.40 ± 5.31 | 39.49 ± 3.03 | 0.1602 |
| Trabecular Number (Tb.N) (#/mm) | 2.80 ± 0.24 | 2.95 ± 0.25 | 0.2566 |
| Trabecular Spacing (Tb.Sp) (µm) | 313.32 ± 30.86 | 288.79 ± 28.17 | 0.1426 |
| Trabecular Thickness (Tb.Th) (µm) | 47.04 ± 2.35 | 56.18 ± 5.21 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.93 ± 1.89 | 19.04 ± 3.59 | 0.0618 |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 7.66 ± 0.89 | 7.23 ± 1.92 | 0.6015 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.00 ± 1.80 | 11.28 ± 2.47 | 0.0163* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 86.91 ± 3.57 | 77.72 ± 3.77 | <0.001* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 49.00 ± 6.11 | 39.01 ± 7.45 | 0.0198* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.00 ± 6.11 | 60.99 ± 7.45 | 0.0198* |