Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Akap11 KO Male
M
12wk
B6N(Cg)-Akap11<tm1b(ECOMM)Hmgu>/J (C57BL/6NTac)
• KO/KO
Akap11 KO Female
F
12wk
B6N(Cg)-Akap11<tm1b(ECOMM)Hmgu>/J (C57BL/6NTac)
• KO/KO
Akap11 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Akap11 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Akap11 WT Male (Mean ± SD) | Akap11 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 50.60 ± 5.88 | 46.09 ± 7.67 | 0.2378 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.00 ± 4.87 | 21.21 ± 4.06 | 0.0058* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 22.01 ± 3.66 | 24.30 ± 4.71 | 0.3250 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.46 ± 0.48 | 1.15 ± 0.40 | <0.001* |
| Body Weight (g) | 27.49 ± 2.14 | 23.92 ± 1.63 | 0.0035* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.366 ± 0.074 | 0.280 ± 0.039 | 0.0171* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.61 ± 1.37 | 22.20 ± 3.60 | <0.001* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.60 ± 5.31 | 46.61 ± 5.21 | 0.0032* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.26 ± 0.16 | 1.37 ± 0.11 | 0.1587 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 28.20 ± 3.69 | 20.89 ± 2.23 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.40 ± 5.31 | 53.39 ± 5.21 | 0.0032* |
| Trabecular Number (Tb.N) (#/mm) | 2.80 ± 0.24 | 3.54 ± 0.50 | 0.0040* |
| Trabecular Spacing (Tb.Sp) (µm) | 313.32 ± 30.86 | 229.91 ± 50.73 | 0.0031* |
| Trabecular Thickness (Tb.Th) (µm) | 47.04 ± 2.35 | 61.89 ± 3.13 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.93 ± 1.89 | 7.37 ± 1.17 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 7.66 ± 0.89 | 2.85 ± 0.88 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.00 ± 1.80 | 4.74 ± 1.35 | 0.0018* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 86.91 ± 3.57 | 87.06 ± 7.56 | 0.9619 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 49.00 ± 6.11 | 37.85 ± 6.20 | 0.0044* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.00 ± 6.11 | 62.15 ± 6.20 | 0.0044* |