Skeletal Phenotyping of Cyp2c23 Knockout Mice

ROSSA-20260926-F6A1

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Cyp2c23 KO Male M 12wk
B6N(Cg)-Cyp2c44<tm1b(EUCOMM)Hmgu>/J (C57BL/6NTac) • KO/KO
Cyp2c23 KO Female F 12wk
B6N(Cg)-Cyp2c44<tm1b(EUCOMM)Hmgu>/J (C57BL/6NTac) • KO/KO
Cyp2c23 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Cyp2c23 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Cyp2c23 WT Male (Mean ± SD) Cyp2c23 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 26.60 ± 2.00 26.64 ± 1.17 0.9650
Bone Mineral Density (mg/ccm HA) 1,140.51 ± 6.23 1,157.21 ± 4.52 <0.001*
Cortical Area (mm^2) 0.648 ± 0.011 0.811 ± 0.069 0.0010*
Cortical Area / Total Area (%) 39.75 ± 0.81 42.97 ± 1.60 <0.001*
Cortical Mask (dimensionless) 0.649 ± 0.011 0.813 ± 0.069 0.0010*
Cortical Porosity (%) 0.252 ± 0.033 0.294 ± 0.088 0.2613
Cortical Thickness (mm) 0.1506 ± 0.0037 0.180 ± 0.014 0.0018*
Endocortical Perimeter (mm) 3.510 ± 0.072 3.668 ± 0.089 0.0035*
Length (mm) 14.60 ± 0.11 15.00 ± 0.17 <0.001*
Marrow Area (mm^2) 0.981 ± 0.040 1.071 ± 0.052 0.0037*
Maximum Distance from Centroid (mm) 1.845 ± 0.049 1.971 ± 0.072 0.0025*
Maximum Moment of Inertia (mm^4) 0.1943 ± 0.0093 0.280 ± 0.042 0.0022*
Minimum Distance from Centroid (mm) 1.185 ± 0.026 1.273 ± 0.042 <0.001*
Minimum Moment of Inertia (mm^4) 0.0952 ± 0.0050 0.133 ± 0.016 0.0010*
Periosteal Perimeter (mm) 4.39 ± 0.11 4.87 ± 0.27 <0.001*
Polar Moment of Inertia (mm^4) 0.290 ± 0.014 0.413 ± 0.058 0.0016*
Pore Area (mm^2) 0.0016 ± 0.0002 0.0024 ± 0.0009 0.0431*
Section Modulus about Maximum Moment of Inertia (mm^3) 0.2107 ± 0.0073 0.284 ± 0.033 0.0015*
Section Modulus about Minimum Moment of Inertia (mm^3) 0.1607 ± 0.0062 0.209 ± 0.021 0.0011*
Tissue Mineral Density (mg/ccm HA) 1,206.41 ± 6.42 1,217.28 ± 6.09 0.0082*
Total Area (mm^2) 1.630 ± 0.047 1.88 ± 0.11 <0.001*