Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Cers5 KO Male
M
12wk
B6N(Cg)-Cers5<tm2b(KOMP)Mbp>/J (C57BL/6NTac)
• KO/KO
Cers5 KO Female
F
12wk
B6N(Cg)-Cers5<tm2b(KOMP)Mbp>/J (C57BL/6NTac)
• KO/KO
Cers5 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Cers5 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Cers5 WT Male (Mean ± SD) | Cers5 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 76.20 ± 3.75 | 61.25 ± 4.79 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 43.65 ± 2.59 | 34.44 ± 3.02 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 33.24 ± 1.57 | 27.54 ± 4.86 | 0.0160* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 4.62 ± 0.82 | 5.07 ± 1.01 | 0.4035 |
| Body Weight (g) | 20.33 ± 0.89 | 20.92 ± 1.12 | 0.2938 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.477 ± 0.073 | 0.414 ± 0.059 | 0.1059 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.63 ± 0.81 | 12.07 ± 0.86 | 0.0059* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.73 ± 1.96 | 55.70 ± 5.49 | 0.6665 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.55 ± 0.14 | 1.418 ± 0.078 | 0.0492* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 31.63 ± 2.25 | 28.97 ± 3.13 | 0.1061 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.27 ± 1.96 | 44.30 ± 5.49 | 0.6665 |
| Trabecular Number (Tb.N) (#/mm) | 2.11 ± 0.15 | 2.50 ± 0.18 | <0.001* |
| Trabecular Spacing (Tb.Sp) (µm) | 428.83 ± 32.50 | 358.38 ± 27.23 | <0.001* |
| Trabecular Thickness (Tb.Th) (µm) | 49.82 ± 2.79 | 48.26 ± 2.60 | 0.2961 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 16.43 ± 3.82 | 21.88 ± 2.80 | 0.0087* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 8.21 ± 1.91 | 10.04 ± 1.82 | 0.1000 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.77 ± 2.47 | 12.09 ± 1.50 | 0.0110* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 85.28 ± 2.97 | 78.35 ± 4.85 | 0.0062* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 48.86 ± 4.36 | 45.19 ± 4.11 | 0.1422 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.14 ± 4.36 | 54.81 ± 4.11 | 0.1422 |