Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Ocstamp KO Male
M
12wk
B6N(Cg)-Ocstamp<tm2b(KOMP)Wtsi>/2J (C57BL/6NTac)
• KO/KO
Ocstamp KO Female
F
12wk
B6N(Cg)-Ocstamp<tm2b(KOMP)Wtsi>/2J (C57BL/6NTac)
• KO/KO
Ocstamp WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Ocstamp WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Ocstamp WT Male (Mean ± SD) | Ocstamp KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 59.29 ± 6.90 | 74.93 ± 2.87 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 32.58 ± 1.62 | 35.38 ± 1.22 | 0.0041* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 26.59 ± 3.40 | 38.90 ± 3.15 | <0.001* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 4.02 ± 1.23 | 6.16 ± 0.86 | 0.0044* |
| Body Weight (g) | 20.78 ± 2.86 | 22.46 ± 1.83 | 0.2119 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.425 ± 0.081 | 0.320 ± 0.026 | 0.0107* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 8.76 ± 1.94 | 12.78 ± 1.64 | <0.001* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 55.10 ± 2.80 | 47.66 ± 2.08 | <0.001* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.59 ± 0.23 | 1.360 ± 0.074 | 0.0325* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 27.70 ± 1.84 | 24.44 ± 0.48 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 44.90 ± 2.80 | 52.34 ± 2.08 | <0.001* |
| Trabecular Number (Tb.N) (#/mm) | 2.00 ± 0.31 | 2.38 ± 0.34 | 0.0447* |
| Trabecular Spacing (Tb.Sp) (µm) | 475.99 ± 85.64 | 377.26 ± 59.91 | 0.0255* |
| Trabecular Thickness (Tb.Th) (µm) | 44.83 ± 4.43 | 54.03 ± 2.16 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 23.77 ± 6.21 | 28.36 ± 3.07 | 0.1095 |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 10.19 ± 2.47 | 11.46 ± 1.16 | 0.2767 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 13.56 ± 3.98 | 17.23 ± 2.11 | 0.0690 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 81.90 ± 6.53 | 78.49 ± 5.31 | 0.3180 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 43.45 ± 2.82 | 39.95 ± 2.38 | 0.0386* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 56.55 ± 2.82 | 60.05 ± 2.38 | 0.0386* |