Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Pycr1 KO Male
M
12wk
B6N(Cg)-Pycr1<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Pycr1 KO Female
F
12wk
B6N(Cg)-Pycr1<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Pycr1 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Pycr1 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Pycr1 WT Male (Mean ± SD) | Pycr1 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 63.27 ± 14.77 | 70.10 ± 2.46 | 0.2478 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 34.78 ± 8.96 | 21.29 ± 3.23 | 0.0027* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 33.78 ± 4.14 | 48.43 ± 1.92 | <0.001* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.67 ± 1.30 | 1.54 ± 0.63 | 0.0020* |
| Body Weight (g) | 25.98 ± 2.26 | 23.45 ± 1.15 | 0.0194* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.354 ± 0.089 | 0.192 ± 0.033 | 0.0015* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.18 ± 2.92 | 12.73 ± 1.21 | 0.7160 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 49.80 ± 6.95 | 30.45 ± 3.87 | <0.001* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.33 ± 0.13 | 1.38 ± 0.15 | 0.5234 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 24.62 ± 4.46 | 13.75 ± 2.21 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 50.20 ± 6.95 | 69.55 ± 3.87 | <0.001* |
| Trabecular Number (Tb.N) (#/mm) | 2.61 ± 0.49 | 2.38 ± 0.24 | 0.2866 |
| Trabecular Spacing (Tb.Sp) (µm) | 348.22 ± 66.42 | 373.80 ± 41.15 | 0.4009 |
| Trabecular Thickness (Tb.Th) (µm) | 49.01 ± 4.51 | 53.58 ± 3.65 | 0.0562 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 17.05 ± 5.33 | 21.89 ± 1.86 | 0.0397* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 6.37 ± 2.72 | 4.24 ± 1.18 | 0.0877 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 10.28 ± 3.86 | 17.19 ± 1.97 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 81.53 ± 3.78 | 76.54 ± 2.78 | 0.0138* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 37.45 ± 9.71 | 19.81 ± 5.30 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 62.55 ± 9.71 | 80.19 ± 5.30 | <0.001* |