Study Datasets
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Nat8f2 KO Male
M
12wk
B6N(Cg)-Cml2 tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Nat8f2 KO Female
F
12wk
B6N(Cg)-Cml2 tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Nat8f2 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Nat8f2 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Vertebra Region: Trabecular
| Variable | Nat8f2 WT Male (Mean ± SD) | Nat8f2 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 78.25 ± 8.65 | 69.70 ± 4.27 | 0.0342* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 33.49 ± 5.13 | 36.27 ± 5.55 | 0.3685 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 43.67 ± 4.60 | 33.90 ± 3.00 | <0.001* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 5.90 ± 0.86 | 8.09 ± 1.95 | 0.0239* |
| Body Weight (g) | 27.39 ± 1.23 | 27.03 ± 1.67 | 0.6524 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.192 ± 0.046 | 0.321 ± 0.048 | <0.001* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 16.08 ± 2.15 | 16.78 ± 4.00 | 0.6880 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 43.23 ± 2.90 | 51.50 ± 5.23 | 0.0042* |
| Mineral Apposition Rate (MAR) (µm/day) | 0.92 ± 0.12 | 1.222 ± 0.093 | <0.001* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 20.76 ± 2.52 | 26.08 ± 3.98 | 0.0141* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 56.77 ± 2.90 | 48.50 ± 5.23 | 0.0042* |
| Trabecular Number (Tb.N) (#/mm) | 3.65 ± 0.43 | 5.93 ± 0.94 | <0.001* |
| Trabecular Spacing (Tb.Sp) (µm) | 235.41 ± 33.41 | 146.95 ± 29.25 | <0.001* |
| Trabecular Thickness (Tb.Th) (µm) | 43.50 ± 3.71 | 28.70 ± 4.58 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 21.33 ± 3.38 | 29.69 ± 3.85 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 8.49 ± 1.42 | 12.70 ± 2.46 | 0.0027* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 12.67 ± 3.02 | 16.61 ± 3.14 | 0.0388* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 85.89 ± 5.06 | 81.29 ± 4.41 | 0.0917 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 40.83 ± 6.52 | 43.34 ± 6.74 | 0.5074 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 59.17 ± 6.52 | 56.66 ± 6.74 | 0.5074 |