Skeletal Phenotyping of Rnf13 Knockout Mice

ROSSA-20260926-E2CA

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Rnf13 KO Male M 12wk
B6N(Cg)-Rnf13<tm1.1(KOPM)Vlcg>/J (C57BL/6NTac) • KO/KO
Rnf13 KO Female F 12wk
B6N(Cg)-Rnf13<tm1.1(KOPM)Vlcg>/J (C57BL/6NTac) • KO/KO
Rnf13 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Rnf13 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Rnf13 WT Male (Mean ± SD) Rnf13 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 25.27 ± 1.24 24.72 ± 1.63 0.5213
Bone Mineral Density (mg/ccm HA) 1,144.06 ± 5.55 1,142.54 ± 3.15 0.5868
Cortical Area (mm^2) 0.666 ± 0.038 0.696 ± 0.074 0.4282
Cortical Area / Total Area (%) 40.54 ± 0.86 37.44 ± 1.00 <0.001*
Cortical Mask (dimensionless) 0.667 ± 0.038 0.699 ± 0.075 0.4213
Cortical Porosity (%) 0.241 ± 0.031 0.34 ± 0.11 0.1003
Cortical Thickness (mm) 0.1555 ± 0.0065 0.1519 ± 0.0093 0.4428
Endocortical Perimeter (mm) 3.498 ± 0.078 3.81 ± 0.21 0.0182*
Length (mm) 14.60 ± 0.11 14.72 ± 0.39 0.5400
Marrow Area (mm^2) 0.974 ± 0.044 1.16 ± 0.13 0.0205*
Maximum Distance from Centroid (mm) 1.858 ± 0.079 1.992 ± 0.095 0.0202*
Maximum Moment of Inertia (mm^4) 0.203 ± 0.026 0.245 ± 0.044 0.0602
Minimum Distance from Centroid (mm) 1.189 ± 0.027 1.27 ± 0.11 0.1359
Minimum Moment of Inertia (mm^4) 0.0973 ± 0.0081 0.120 ± 0.029 0.1420
Periosteal Perimeter (mm) 4.39 ± 0.13 4.85 ± 0.45 0.0717
Polar Moment of Inertia (mm^4) 0.300 ± 0.034 0.365 ± 0.072 0.1048
Pore Area (mm^2) 0.0016 ± 0.0002 0.0024 ± 0.0010 0.1278
Section Modulus about Maximum Moment of Inertia (mm^3) 0.218 ± 0.019 0.244 ± 0.034 0.1114
Section Modulus about Minimum Moment of Inertia (mm^3) 0.164 ± 0.011 0.186 ± 0.030 0.1600
Tissue Mineral Density (mg/ccm HA) 1,208.77 ± 4.85 1,209.16 ± 3.37 0.8798
Total Area (mm^2) 1.642 ± 0.077 1.86 ± 0.20 0.0568