Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Fndc4 KO Male
M
12wk
B6N(Cg)-Fndc4<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Fndc4 KO Female
F
12wk
B6N(Cg)-Fndc4<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Fndc4 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Fndc4 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Fndc4 WT Male (Mean ± SD) | Fndc4 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 50.60 ± 5.88 | 44.49 ± 9.50 | 0.1957 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.00 ± 4.87 | 24.47 ± 4.53 | 0.1265 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 22.01 ± 3.66 | 20.26 ± 5.76 | 0.5349 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.46 ± 0.48 | 3.01 ± 1.07 | 0.3548 |
| Body Weight (g) | 27.49 ± 2.14 | 23.40 ± 1.03 | 0.0018* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.366 ± 0.074 | 0.335 ± 0.062 | 0.4626 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.61 ± 1.37 | 10.47 ± 1.28 | 0.0016* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.60 ± 5.31 | 55.14 ± 4.43 | 0.6204 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.26 ± 0.16 | 1.26 ± 0.18 | 0.9949 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 28.20 ± 3.69 | 26.01 ± 2.43 | 0.2646 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.40 ± 5.31 | 44.86 ± 4.43 | 0.6204 |
| Trabecular Number (Tb.N) (#/mm) | 2.80 ± 0.24 | 2.12 ± 0.21 | <0.001* |
| Trabecular Spacing (Tb.Sp) (µm) | 313.32 ± 30.86 | 430.42 ± 50.12 | <0.001* |
| Trabecular Thickness (Tb.Th) (µm) | 47.04 ± 2.35 | 49.28 ± 3.01 | 0.1729 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.93 ± 1.89 | 19.72 ± 2.26 | 0.0082* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 7.66 ± 0.89 | 7.80 ± 1.71 | 0.8663 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.00 ± 1.80 | 11.59 ± 1.29 | 0.0023* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 86.91 ± 3.57 | 76.85 ± 3.24 | <0.001* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 49.00 ± 6.11 | 40.89 ± 4.21 | 0.0238* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.00 ± 6.11 | 59.11 ± 4.21 | 0.0238* |