Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Htr1d KO Male
M
12wk
B6N(Cg)-Htr1d<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Htr1d KO Female
F
12wk
B6N(Cg)-Htr1d<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Htr1d WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Htr1d WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Htr1d WT Male (Mean ± SD) | Htr1d KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 76.20 ± 3.75 | 67.60 ± 5.08 | 0.0039* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 43.65 ± 2.59 | 38.97 ± 4.28 | 0.0719 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 33.24 ± 1.57 | 29.64 ± 3.13 | 0.0471* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 4.62 ± 0.82 | 7.55 ± 2.73 | 0.1586 |
| Body Weight (g) | 20.33 ± 0.89 | 19.65 ± 1.49 | 0.3301 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.477 ± 0.073 | 0.398 ± 0.038 | 0.0995 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.63 ± 0.81 | 9.45 ± 2.13 | 0.2419 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.73 ± 1.96 | 56.72 ± 3.24 | 0.9938 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.55 ± 0.14 | 1.38 ± 0.15 | 0.0837 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 31.63 ± 2.25 | 30.25 ± 2.45 | 0.4134 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.27 ± 1.96 | 43.28 ± 3.24 | 0.9938 |
| Trabecular Number (Tb.N) (#/mm) | 2.11 ± 0.15 | 2.06 ± 0.46 | 0.8098 |
| Trabecular Spacing (Tb.Sp) (µm) | 428.83 ± 32.50 | 473.53 ± 103.05 | 0.3416 |
| Trabecular Thickness (Tb.Th) (µm) | 49.82 ± 2.79 | 42.39 ± 3.27 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 16.43 ± 3.82 | 26.74 ± 6.64 | 0.0040* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 8.21 ± 1.91 | 12.30 ± 3.38 | 0.1230 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.77 ± 2.47 | 13.05 ± 3.91 | 0.0751 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 85.28 ± 2.97 | 81.74 ± 6.15 | 0.2015 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 48.86 ± 4.36 | 48.65 ± 1.26 | 0.9317 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.14 ± 4.36 | 51.35 ± 1.26 | 0.9317 |