Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Hsd17b11 KO Male
M
12wk
B6N(Cg)-Hsd17b11<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Hsd17b11 KO Female
F
12wk
B6N(Cg)-Hsd17b11<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Hsd17b11 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Hsd17b11 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Hsd17b11 WT Male (Mean ± SD) | Hsd17b11 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 39.31 ± 3.67 | 69.63 ± 2.95 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 15.73 ± 2.61 | 31.06 ± 2.43 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 24.34 ± 3.62 | 37.79 ± 2.30 | <0.001* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 2.06 ± 0.63 | 2.52 ± 0.75 | 0.3141 |
| Body Weight (g) | 26.74 ± 1.76 | 25.07 ± 2.39 | 0.1585 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.228 ± 0.054 | 0.317 ± 0.020 | 0.0041* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 15.99 ± 2.73 | 17.96 ± 2.87 | 0.2687 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 39.51 ± 6.73 | 45.06 ± 2.23 | 0.1111 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.322 ± 0.080 | 1.350 ± 0.064 | 0.4975 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 17.59 ± 2.51 | 23.70 ± 1.62 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 60.49 ± 6.73 | 54.94 ± 2.23 | 0.1111 |
| Trabecular Number (Tb.N) (#/mm) | 2.95 ± 0.42 | 3.26 ± 0.40 | 0.2375 |
| Trabecular Spacing (Tb.Sp) (µm) | 295.45 ± 49.62 | 258.39 ± 40.88 | 0.2079 |
| Trabecular Thickness (Tb.Th) (µm) | 50.85 ± 6.46 | 51.20 ± 6.41 | 0.9205 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 14.26 ± 3.83 | 18.15 ± 2.94 | 0.0511 |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 3.87 ± 1.40 | 6.18 ± 0.85 | 0.0079* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 10.25 ± 2.97 | 11.74 ± 1.23 | 0.3130 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 77.44 ± 4.98 | 83.37 ± 8.22 | 0.1248 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 26.92 ± 2.59 | 33.90 ± 4.44 | 0.0079* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 73.08 ± 2.59 | 66.10 ± 4.44 | 0.0079* |