Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Sh3tc2 KO Male
M
12wk
B6N(Cg)-Sh3tc2 tm1b(KOMP)Wtsi/J (C57BL/6NTac)
• KO/KO
Sh3tc2 KO Female
F
12wk
B6N(Cg)-Sh3tc2 tm1b(KOMP)Wtsi/J (C57BL/6NTac)
• KO/KO
Sh3tc2 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Sh3tc2 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Sh3tc2 WT Male (Mean ± SD) | Sh3tc2 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 60.29 ± 4.51 | 66.81 ± 11.65 | 0.1962 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 27.86 ± 3.44 | 36.41 ± 5.68 | 0.0055* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 34.61 ± 3.71 | 32.27 ± 7.32 | 0.4725 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 4.01 ± 0.83 | 1.97 ± 0.71 | <0.001* |
| Body Weight (g) | 26.54 ± 1.53 | 24.55 ± 1.87 | 0.0470* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.301 ± 0.039 | 0.546 ± 0.047 | <0.001* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.22 ± 2.53 | 13.10 ± 1.96 | 0.0317* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 44.53 ± 3.76 | 53.41 ± 3.93 | 0.0011* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.42 ± 0.14 | 1.95 ± 0.17 | <0.001* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 21.39 ± 2.38 | 28.02 ± 1.78 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 55.47 ± 3.76 | 46.59 ± 3.93 | 0.0011* |
| Trabecular Number (Tb.N) (#/mm) | 2.38 ± 0.30 | 4.08 ± 0.38 | <0.001* |
| Trabecular Spacing (Tb.Sp) (µm) | 386.73 ± 55.78 | 218.29 ± 23.92 | <0.001* |
| Trabecular Thickness (Tb.Th) (µm) | 42.65 ± 6.61 | 31.28 ± 3.24 | 0.0011* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 29.22 ± 1.87 | 11.93 ± 1.96 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 9.13 ± 1.11 | 4.41 ± 1.15 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 20.00 ± 1.65 | 6.40 ± 1.58 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 74.49 ± 3.85 | 83.57 ± 8.26 | 0.0196* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 31.32 ± 3.56 | 43.32 ± 4.29 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 68.68 ± 3.56 | 56.68 ± 4.29 | <0.001* |