Skeletal Phenotyping of Hc Knockout Mice

ROSSA-20260926-DBA6

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Hc KO Male M 12wk
B6N(Cg)-Hc<tm1b(EUCOMM)Wtsi>/J (C57BL/6NTac) • KO/KO
Hc KO Female F 12wk
B6N(Cg)-Hc<tm1b(EUCOMM)Wtsi>/J (C57BL/6NTac) • KO/KO
Hc WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Hc WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Hc WT Male (Mean ± SD) Hc KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 26.07 ± 1.17 24.74 ± 1.86 0.1317
Bone Mineral Density (mg/ccm HA) 1,160.31 ± 10.68 1,153.54 ± 9.48 0.2297
Cortical Area (mm^2) 0.723 ± 0.048 0.712 ± 0.066 0.7315
Cortical Area / Total Area (%) 42.04 ± 2.28 40.49 ± 1.47 0.1527
Cortical Mask (dimensionless) 0.725 ± 0.048 0.714 ± 0.066 0.7326
Cortical Porosity (%) 0.268 ± 0.023 0.278 ± 0.044 0.5984
Cortical Thickness (mm) 0.165 ± 0.011 0.162 ± 0.012 0.6215
Endocortical Perimeter (mm) 3.534 ± 0.078 3.62 ± 0.11 0.1317
Length (mm) 14.76 ± 0.12 14.69 ± 0.19 0.3839
Marrow Area (mm^2) 0.994 ± 0.044 1.042 ± 0.066 0.1286
Maximum Distance from Centroid (mm) 1.909 ± 0.058 1.910 ± 0.080 0.9738
Maximum Moment of Inertia (mm^4) 0.223 ± 0.017 0.226 ± 0.033 0.8482
Minimum Distance from Centroid (mm) 1.221 ± 0.027 1.247 ± 0.061 0.3069
Minimum Moment of Inertia (mm^4) 0.1109 ± 0.0093 0.114 ± 0.018 0.6762
Periosteal Perimeter (mm) 4.549 ± 0.090 4.58 ± 0.19 0.6678
Polar Moment of Inertia (mm^4) 0.334 ± 0.025 0.340 ± 0.050 0.7806
Pore Area (mm^2) 0.0019 ± 0.0002 0.0020 ± 0.0003 0.7674
Section Modulus about Maximum Moment of Inertia (mm^3) 0.234 ± 0.013 0.236 ± 0.026 0.8585
Section Modulus about Minimum Moment of Inertia (mm^3) 0.182 ± 0.012 0.182 ± 0.021 0.9405
Tissue Mineral Density (mg/ccm HA) 1,225.85 ± 8.99 1,218.85 ± 8.90 0.1651
Total Area (mm^2) 1.719 ± 0.050 1.76 ± 0.12 0.4708