Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Tprn KO Male
M
12wk
B6N(Cg)-Tprntm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Tprn KO Female
F
12wk
B6N(Cg)-Tprntm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Tprn WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Tprn WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Tprn WT Male (Mean ± SD) | Tprn KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 44.75 ± 7.75 | 41.50 ± 4.72 | 0.3856 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 24.33 ± 3.15 | 27.10 ± 3.12 | 0.2192 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 25.25 ± 3.89 | 20.23 ± 3.87 | 0.0853 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 2.05 ± 1.33 | 3.32 ± 0.30 | 0.0885 |
| Body Weight (g) | 23.58 ± 2.52 | 22.52 ± 1.99 | 0.3995 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.355 ± 0.100 | 0.598 ± 0.052 | 0.0010* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.05 ± 2.91 | 8.60 ± 1.37 | 0.2537 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 49.20 ± 4.06 | 57.63 ± 2.26 | 0.0046* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.65 ± 0.22 | 2.04 ± 0.15 | 0.0038* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 21.67 ± 3.85 | 28.92 ± 1.51 | 0.0045* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 50.80 ± 4.06 | 42.37 ± 2.26 | 0.0046* |
| Trabecular Number (Tb.N) (#/mm) | 2.13 ± 0.39 | 2.81 ± 0.74 | 0.0472* |
| Trabecular Spacing (Tb.Sp) (µm) | 449.34 ± 102.10 | 356.91 ± 109.19 | 0.1241 |
| Trabecular Thickness (Tb.Th) (µm) | 45.69 ± 6.15 | 32.02 ± 5.33 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.43 ± 9.10 | 23.33 ± 1.79 | 0.0562 |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 5.35 ± 4.35 | 9.63 ± 1.34 | 0.1172 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.77 ± 5.70 | 13.34 ± 2.57 | 0.2026 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 76.42 ± 6.50 | 74.28 ± 6.69 | 0.5531 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 32.93 ± 11.47 | 42.25 ± 7.28 | 0.2178 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 67.07 ± 11.47 | 57.75 ± 7.28 | 0.2178 |