Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Zfp40 KO Male
M
12wk
B6N(Cg)-Zfp40<tm1b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Zfp40 KO Female
F
12wk
B6N(Cg)-Zfp40<tm1b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Zfp40 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Zfp40 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Zfp40 WT Male (Mean ± SD) | Zfp40 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 50.60 ± 5.88 | 73.54 ± 3.59 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.00 ± 4.87 | 52.84 ± 3.79 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 22.01 ± 3.66 | 20.77 ± 2.89 | 0.4944 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.46 ± 0.48 | 7.86 ± 1.87 | <0.001* |
| Body Weight (g) | 27.49 ± 2.14 | 27.53 ± 1.68 | 0.9677 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.366 ± 0.074 | 0.558 ± 0.066 | <0.001* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.61 ± 1.37 | 16.67 ± 2.59 | 0.0153* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.60 ± 5.31 | 71.77 ± 3.40 | <0.001* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.26 ± 0.16 | 1.36 ± 0.10 | 0.1951 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 28.20 ± 3.69 | 40.38 ± 2.01 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.40 ± 5.31 | 28.23 ± 3.40 | <0.001* |
| Trabecular Number (Tb.N) (#/mm) | 2.80 ± 0.24 | 3.06 ± 0.33 | 0.1147 |
| Trabecular Spacing (Tb.Sp) (µm) | 313.32 ± 30.86 | 279.40 ± 36.11 | 0.0797 |
| Trabecular Thickness (Tb.Th) (µm) | 47.04 ± 2.35 | 54.43 ± 4.38 | 0.0015* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.93 ± 1.89 | 20.66 ± 4.02 | 0.0137* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 7.66 ± 0.89 | 12.25 ± 2.99 | 0.0016* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.00 ± 1.80 | 7.06 ± 1.95 | 0.3648 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 86.91 ± 3.57 | 88.22 ± 2.43 | 0.4355 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 49.00 ± 6.11 | 63.69 ± 4.77 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.00 ± 6.11 | 36.31 ± 4.77 | <0.001* |