Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Ces4a KO Male
M
12wk
B6N(Cg)-Ces4a<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Ces4a KO Female
F
12wk
B6N(Cg)-Ces4a<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Ces4a WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Ces4a WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Ces4a WT Male (Mean ± SD) | Ces4a KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 46.91 ± 3.79 | 46.20 ± 7.13 | 0.8331 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 25.14 ± 2.85 | 23.50 ± 2.36 | 0.4563 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 20.75 ± 3.87 | 22.99 ± 7.78 | 0.6017 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 2.07 ± 0.55 | 1.90 ± 0.84 | 0.7395 |
| Body Weight (g) | 24.87 ± 2.15 | 22.76 ± 1.25 | 0.0943 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.309 ± 0.046 | 0.329 ± 0.059 | 0.6690 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.94 ± 1.74 | 11.43 ± 1.07 | 0.0216* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 55.05 ± 6.67 | 51.86 ± 8.56 | 0.5865 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.36 ± 0.15 | 1.70 ± 0.54 | 0.1546 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 25.56 ± 3.66 | 23.57 ± 4.32 | 0.5233 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 44.95 ± 6.67 | 48.14 ± 8.56 | 0.5865 |
| Trabecular Number (Tb.N) (#/mm) | 2.59 ± 0.30 | 2.25 ± 0.22 | 0.0700 |
| Trabecular Spacing (Tb.Sp) (µm) | 337.35 ± 46.10 | 403.09 ± 47.12 | 0.0434* |
| Trabecular Thickness (Tb.Th) (µm) | 56.60 ± 4.00 | 51.00 ± 1.75 | 0.0198* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 12.11 ± 2.08 | 11.37 ± 3.35 | 0.6596 |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 4.81 ± 1.10 | 4.38 ± 1.51 | 0.6666 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 6.75 ± 1.69 | 7.56 ± 2.91 | 0.6346 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 87.38 ± 5.00 | 78.35 ± 4.94 | 0.0137* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 41.85 ± 8.33 | 34.82 ± 5.43 | 0.2638 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 58.15 ± 8.33 | 65.18 ± 5.43 | 0.2638 |