Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Lipn KO Male
M
12wk
B6N(Cg)-Lipn<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Lipn KO Female
F
12wk
B6N(Cg)-Lipn<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Lipn WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Lipn WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Lipn WT Male (Mean ± SD) | Lipn KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 58.80 ± 10.01 | 54.42 ± 4.47 | 0.3078 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 30.75 ± 2.99 | 25.31 ± 4.11 | 0.0166* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 27.98 ± 7.36 | 28.82 ± 5.24 | 0.8185 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 4.33 ± 0.88 | 2.19 ± 0.70 | <0.001* |
| Body Weight (g) | 24.39 ± 2.97 | 26.12 ± 2.91 | 0.2896 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.361 ± 0.034 | 0.285 ± 0.081 | 0.0428* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.75 ± 3.10 | 13.53 ± 1.98 | 0.0651 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 53.00 ± 5.82 | 46.76 ± 7.69 | 0.1205 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.39 ± 0.18 | 1.25 ± 0.13 | 0.1275 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 26.34 ± 2.98 | 22.55 ± 4.95 | 0.1138 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 47.00 ± 5.82 | 53.24 ± 7.69 | 0.1205 |
| Trabecular Number (Tb.N) (#/mm) | 2.33 ± 0.47 | 2.55 ± 0.39 | 0.3765 |
| Trabecular Spacing (Tb.Sp) (µm) | 412.20 ± 104.20 | 358.29 ± 65.08 | 0.2911 |
| Trabecular Thickness (Tb.Th) (µm) | 43.98 ± 5.09 | 55.48 ± 3.01 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 20.56 ± 4.92 | 15.73 ± 2.17 | 0.0324* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 8.70 ± 1.26 | 5.12 ± 1.29 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 12.11 ± 4.46 | 10.48 ± 1.72 | 0.4123 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 81.59 ± 7.40 | 82.80 ± 3.84 | 0.7067 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 43.75 ± 7.85 | 32.70 ± 6.41 | 0.0164* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 56.25 ± 7.85 | 67.30 ± 6.41 | 0.0164* |