Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Cited4 KO Male
M
12wk
B6N(Cg)-Cited4tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Cited4 KO Female
F
12wk
B6N(Cg)-Cited4tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Cited4 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Cited4 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Cited4 WT Male (Mean ± SD) | Cited4 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 44.46 ± 11.02 | 60.24 ± 9.97 | 0.0140* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 18.07 ± 6.10 | 22.69 ± 7.26 | 0.2759 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 26.89 ± 6.21 | 35.06 ± 3.47 | 0.0232* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 1.00 ± 0.70 | 1.83 ± 0.43 | 0.0410* |
| Body Weight (g) | 25.69 ± 2.19 | 25.22 ± 2.08 | 0.6870 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.282 ± 0.046 | 0.262 ± 0.083 | 0.6278 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 12.31 ± 2.31 | 11.31 ± 2.39 | 0.4386 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 39.78 ± 4.86 | 38.12 ± 6.11 | 0.6255 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.61 ± 0.19 | 1.48 ± 0.38 | 0.4774 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 17.34 ± 1.83 | 18.53 ± 3.96 | 0.5254 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 60.22 ± 4.86 | 61.88 ± 6.11 | 0.6255 |
| Trabecular Number (Tb.N) (#/mm) | 2.56 ± 0.33 | 3.82 ± 0.48 | <0.001* |
| Trabecular Spacing (Tb.Sp) (µm) | 354.28 ± 55.48 | 238.43 ± 37.88 | <0.001* |
| Trabecular Thickness (Tb.Th) (µm) | 46.39 ± 5.15 | 29.20 ± 3.84 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 12.98 ± 2.15 | 17.57 ± 1.41 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 3.48 ± 1.02 | 5.24 ± 0.54 | 0.0052* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 9.83 ± 1.70 | 12.97 ± 2.01 | 0.0172* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 76.32 ± 5.39 | 79.35 ± 6.96 | 0.3783 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 25.72 ± 5.07 | 29.09 ± 4.15 | 0.2582 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 74.28 ± 5.07 | 70.92 ± 4.15 | 0.2582 |