Skeletal Phenotyping of Ptpn20 Knockout Mice

ROSSA-20260926-BE64

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Ptpn20 KO Male M 12wk
B6N(Cg)-Ptpn20<tm1b(KOMP)Wtsi>/J (C57BL/6NTac) • KO/KO
Ptpn20 KO Female F 12wk
B6N(Cg)-Ptpn20<tm1b(KOMP)Wtsi>/J (C57BL/6NTac) • KO/KO
Ptpn20 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Ptpn20 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Ptpn20 WT Male (Mean ± SD) Ptpn20 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 26.60 ± 2.00 26.00 ± 0.90 0.4826
Bone Mineral Density (mg/ccm HA) 1,140.51 ± 6.23 1,153.09 ± 10.05 0.0160*
Cortical Area (mm^2) 0.648 ± 0.011 0.799 ± 0.043 <0.001*
Cortical Area / Total Area (%) 39.75 ± 0.81 42.23 ± 0.92 <0.001*
Cortical Mask (dimensionless) 0.649 ± 0.011 0.801 ± 0.043 <0.001*
Cortical Porosity (%) 0.252 ± 0.033 0.259 ± 0.047 0.7220
Cortical Thickness (mm) 0.1506 ± 0.0037 0.1777 ± 0.0058 <0.001*
Endocortical Perimeter (mm) 3.510 ± 0.072 3.702 ± 0.076 <0.001*
Length (mm) 14.60 ± 0.11 14.71 ± 0.16 0.1383
Marrow Area (mm^2) 0.981 ± 0.040 1.091 ± 0.045 <0.001*
Maximum Distance from Centroid (mm) 1.845 ± 0.049 1.979 ± 0.070 <0.001*
Maximum Moment of Inertia (mm^4) 0.1943 ± 0.0093 0.266 ± 0.026 <0.001*
Minimum Distance from Centroid (mm) 1.185 ± 0.026 1.321 ± 0.044 <0.001*
Minimum Moment of Inertia (mm^4) 0.0952 ± 0.0050 0.137 ± 0.013 <0.001*
Periosteal Perimeter (mm) 4.39 ± 0.11 4.73 ± 0.14 <0.001*
Polar Moment of Inertia (mm^4) 0.290 ± 0.014 0.403 ± 0.038 <0.001*
Pore Area (mm^2) 0.0016 ± 0.0002 0.0021 ± 0.0003 0.0114*
Section Modulus about Maximum Moment of Inertia (mm^3) 0.2107 ± 0.0073 0.268 ± 0.017 <0.001*
Section Modulus about Minimum Moment of Inertia (mm^3) 0.1607 ± 0.0062 0.208 ± 0.013 <0.001*
Tissue Mineral Density (mg/ccm HA) 1,206.41 ± 6.42 1,211.91 ± 10.34 0.2557
Total Area (mm^2) 1.630 ± 0.047 1.892 ± 0.081 <0.001*