Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Ceacam16 KO Male
M
12wk
B6N(Cg)-Ceacam16tm1.1(KOMP)Wtsi/J (C57BL/6NTac)
• KO/KO
Ceacam16 KO Female
F
12wk
B6N(Cg)-Ceacam16tm1.1(KOMP)Wtsi/J (C57BL/6NTac)
• KO/KO
Ceacam16 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Ceacam16 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Ceacam16 WT Male (Mean ± SD) | Ceacam16 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 48.34 ± 6.60 | 30.56 ± 5.19 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 27.33 ± 3.95 | 20.13 ± 4.76 | 0.0296* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 22.50 ± 3.62 | 14.45 ± 4.12 | 0.0101* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.23 ± 1.41 | 1.50 ± 0.57 | 0.0561 |
| Body Weight (g) | 21.37 ± 2.19 | 21.36 ± 1.28 | 0.9919 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.415 ± 0.065 | 0.334 ± 0.095 | 0.1212 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 9.06 ± 1.36 | 7.76 ± 0.68 | 0.0714 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 54.73 ± 3.77 | 57.94 ± 7.16 | 0.5067 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.52 ± 0.25 | 1.30 ± 0.11 | 0.1126 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 27.05 ± 3.01 | 26.07 ± 4.59 | 0.6787 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 45.27 ± 3.77 | 42.06 ± 7.16 | 0.5067 |
| Trabecular Number (Tb.N) (#/mm) | 2.10 ± 0.22 | 1.85 ± 0.17 | 0.0535 |
| Trabecular Spacing (Tb.Sp) (µm) | 449.58 ± 57.33 | 508.91 ± 46.60 | 0.0791 |
| Trabecular Thickness (Tb.Th) (µm) | 44.15 ± 3.15 | 41.06 ± 2.43 | 0.0889 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 21.00 ± 4.56 | 11.71 ± 2.93 | 0.0016* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 9.10 ± 2.56 | 4.08 ± 1.38 | 0.0034* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 12.26 ± 2.77 | 5.12 ± 1.32 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 78.38 ± 4.16 | 76.24 ± 6.10 | 0.4847 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 42.76 ± 5.84 | 44.21 ± 3.66 | 0.6548 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 57.24 ± 5.84 | 55.79 ± 3.66 | 0.6548 |