Skeletal Phenotyping of Steap2 Knockout Mice

ROSSA-20260926-BA61

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Steap2 KO Male M 12wk
B6N(Cg)-Steap2<tm1b(EUCOMM)Hmgu>/J (C57BL/6NTac) • KO/KO
Steap2 KO Female F 12wk
B6N(Cg)-Steap2<tm1b(EUCOMM)Hmgu>/J (C57BL/6NTac) • KO/KO
Steap2 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Steap2 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Steap2 WT Male (Mean ± SD) Steap2 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 25.09 ± 1.37 24.75 ± 1.06 0.6079
Bone Mineral Density (mg/ccm HA) 1,142.86 ± 8.34 1,145.36 ± 7.76 0.5714
Cortical Area (mm^2) 0.751 ± 0.063 0.715 ± 0.056 0.2726
Cortical Area / Total Area (%) 40.70 ± 1.60 40.13 ± 2.00 0.5685
Cortical Mask (dimensionless) 0.753 ± 0.064 0.717 ± 0.056 0.2709
Cortical Porosity (%) 0.268 ± 0.032 0.243 ± 0.017 0.0924
Cortical Thickness (mm) 0.166 ± 0.011 0.161 ± 0.013 0.4317
Endocortical Perimeter (mm) 3.70 ± 0.16 3.65 ± 0.11 0.5232
Length (mm) 14.86 ± 0.24 14.80 ± 0.18 0.6215
Marrow Area (mm^2) 1.093 ± 0.093 1.064 ± 0.065 0.5125
Maximum Distance from Centroid (mm) 1.971 ± 0.090 1.923 ± 0.092 0.3392
Maximum Moment of Inertia (mm^4) 0.254 ± 0.037 0.231 ± 0.032 0.2252
Minimum Distance from Centroid (mm) 1.263 ± 0.069 1.262 ± 0.048 0.9929
Minimum Moment of Inertia (mm^4) 0.125 ± 0.021 0.116 ± 0.012 0.3565
Periosteal Perimeter (mm) 4.79 ± 0.29 4.67 ± 0.19 0.3815
Polar Moment of Inertia (mm^4) 0.379 ± 0.058 0.346 ± 0.043 0.2570
Pore Area (mm^2) 0.0020 ± 0.0004 0.0017 ± 0.0002 0.1059
Section Modulus about Maximum Moment of Inertia (mm^3) 0.257 ± 0.027 0.239 ± 0.023 0.2034
Section Modulus about Minimum Moment of Inertia (mm^3) 0.196 ± 0.023 0.183 ± 0.014 0.2164
Tissue Mineral Density (mg/ccm HA) 1,202.92 ± 8.43 1,210.21 ± 7.19 0.1037
Total Area (mm^2) 1.85 ± 0.15 1.781 ± 0.098 0.3417