Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
4921509C19Rik KO Male
M
12wk
B6N(Cg)-4921509C19Rik<1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
4921509C19Rik KO Female
F
12wk
B6N(Cg)-4921509C19Rik<1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
4921509C19Rik WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
4921509C19Rik WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | 4921509C19Rik WT Male (Mean ± SD) | 4921509C19Rik KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 76.20 ± 3.75 | 69.22 ± 5.54 | 0.0153* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 43.65 ± 2.59 | 34.34 ± 5.53 | 0.0022* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 33.24 ± 1.57 | 35.70 ± 3.52 | 0.1354 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 4.62 ± 0.82 | 4.10 ± 0.59 | 0.2336 |
| Body Weight (g) | 20.33 ± 0.89 | 21.94 ± 1.66 | 0.0400* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.477 ± 0.073 | 0.348 ± 0.048 | 0.0021* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.63 ± 0.81 | 9.86 ± 1.11 | 0.1618 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.73 ± 1.96 | 48.65 ± 5.26 | 0.0043* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.55 ± 0.14 | 1.44 ± 0.12 | 0.1618 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 31.63 ± 2.25 | 24.73 ± 3.76 | 0.0017* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.27 ± 1.96 | 51.35 ± 5.26 | 0.0043* |
| Trabecular Number (Tb.N) (#/mm) | 2.11 ± 0.15 | 2.03 ± 0.27 | 0.5106 |
| Trabecular Spacing (Tb.Sp) (µm) | 428.83 ± 32.50 | 466.35 ± 86.71 | 0.3018 |
| Trabecular Thickness (Tb.Th) (µm) | 49.82 ± 2.79 | 48.23 ± 5.82 | 0.5250 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 16.43 ± 3.82 | 22.32 ± 2.10 | 0.0049* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 8.21 ± 1.91 | 8.87 ± 0.81 | 0.4541 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.77 ± 2.47 | 13.78 ± 2.11 | 0.0026* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 85.28 ± 2.97 | 73.25 ± 5.39 | <0.001* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 48.86 ± 4.36 | 39.73 ± 3.96 | 0.0025* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.14 ± 4.36 | 60.27 ± 3.96 | 0.0025* |