Skeletal Phenotyping of Rab20 Knockout Mice

ROSSA-20260926-B383

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Rab20 KO Male M 12wk
B6N(Cg)-Rab20<tm1b(EUCOMM)Hmgu>/J (C57BL/6NTac) • KO/KO
Rab20 KO Female F 12wk
B6N(Cg)-Rab20<tm1b(EUCOMM)Hmgu>/J (C57BL/6NTac) • KO/KO
Rab20 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Rab20 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Rab20 WT Male (Mean ± SD) Rab20 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 24.28 ± 2.82 23.21 ± 1.80 0.4141
Bone Mineral Density (mg/ccm HA) 1,147.62 ± 4.76 1,147.82 ± 9.74 0.9620
Cortical Area (mm^2) 0.716 ± 0.090 0.680 ± 0.076 0.4367
Cortical Area / Total Area (%) 41.40 ± 2.41 40.63 ± 1.81 0.5070
Cortical Mask (dimensionless) 0.718 ± 0.091 0.682 ± 0.076 0.4385
Cortical Porosity (%) 0.243 ± 0.035 0.256 ± 0.044 0.5687
Cortical Thickness (mm) 0.1641 ± 0.0090 0.159 ± 0.014 0.4605
Endocortical Perimeter (mm) 3.57 ± 0.37 3.52 ± 0.15 0.7609
Length (mm) 14.75 ± 0.41 14.50 ± 0.23 0.1836
Marrow Area (mm^2) 1.03 ± 0.20 0.990 ± 0.087 0.6829
Maximum Distance from Centroid (mm) 1.89 ± 0.20 1.87 ± 0.12 0.8032
Maximum Moment of Inertia (mm^4) 0.227 ± 0.070 0.211 ± 0.047 0.6298
Minimum Distance from Centroid (mm) 1.258 ± 0.087 1.223 ± 0.053 0.3840
Minimum Moment of Inertia (mm^4) 0.116 ± 0.032 0.102 ± 0.018 0.3344
Periosteal Perimeter (mm) 4.57 ± 0.60 4.38 ± 0.29 0.4643
Polar Moment of Inertia (mm^4) 0.34 ± 0.10 0.314 ± 0.065 0.5248
Pore Area (mm^2) 0.0018 ± 0.0004 0.0018 ± 0.0004 0.9561
Section Modulus about Maximum Moment of Inertia (mm^3) 0.235 ± 0.050 0.225 ± 0.035 0.6550
Section Modulus about Minimum Moment of Inertia (mm^3) 0.182 ± 0.039 0.166 ± 0.025 0.3838
Tissue Mineral Density (mg/ccm HA) 1,211.00 ± 5.97 1,212.74 ± 11.65 0.7303
Total Area (mm^2) 1.74 ± 0.29 1.67 ± 0.15 0.5793