Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Pitx3 KO Male
M
12wk
B6N(Cg)-Pitx3<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Pitx3 KO Female
F
12wk
B6N(Cg)-Pitx3<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Pitx3 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Pitx3 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Pitx3 WT Male (Mean ± SD) | Pitx3 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 63.09 ± 8.31 | 63.75 ± 4.29 | 0.8631 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 36.41 ± 5.96 | 34.89 ± 4.19 | 0.6316 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 27.47 ± 3.28 | 29.69 ± 3.62 | 0.3142 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 5.99 ± 1.39 | 5.73 ± 1.43 | 0.7612 |
| Body Weight (g) | 24.25 ± 1.08 | 18.48 ± 1.28 | <0.001* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.447 ± 0.066 | 0.384 ± 0.068 | 0.1135 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.02 ± 1.74 | 9.15 ± 1.22 | 0.3151 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.80 ± 3.21 | 54.06 ± 4.16 | 0.2527 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.457 ± 0.065 | 1.44 ± 0.11 | 0.7516 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 29.86 ± 3.40 | 27.29 ± 3.18 | 0.1823 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.20 ± 3.21 | 45.94 ± 4.16 | 0.2527 |
| Trabecular Number (Tb.N) (#/mm) | 2.32 ± 0.30 | 2.057 ± 0.074 | 0.0423* |
| Trabecular Spacing (Tb.Sp) (µm) | 396.65 ± 65.14 | 445.07 ± 19.45 | 0.0850 |
| Trabecular Thickness (Tb.Th) (µm) | 45.71 ± 4.15 | 43.91 ± 4.08 | 0.4248 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 26.56 ± 5.06 | 25.44 ± 2.58 | 0.6107 |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 11.97 ± 2.03 | 11.36 ± 1.91 | 0.6074 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 14.29 ± 3.85 | 14.14 ± 2.27 | 0.9357 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 76.82 ± 4.86 | 78.81 ± 5.74 | 0.4962 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 46.12 ± 4.92 | 44.73 ± 5.95 | 0.6730 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 53.88 ± 4.92 | 55.27 ± 5.95 | 0.6730 |