Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Fam186b KO Male
M
12wk
B6N(Cg)-Fam186b<tm1b(KOMP)Mbp>/J (C57BL/6NTac)
• KO/KO
Fam186b KO Female
F
12wk
B6N(Cg)-Fam186b<tm1b(KOMP)Mbp>/J (C57BL/6NTac)
• KO/KO
Fam186b WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Fam186b WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Fam186b WT Male (Mean ± SD) | Fam186b KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 50.60 ± 5.88 | 41.81 ± 12.49 | 0.1143 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.00 ± 4.87 | 23.73 ± 6.30 | 0.1130 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 22.01 ± 3.66 | 20.87 ± 7.19 | 0.7204 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.46 ± 0.48 | 1.19 ± 0.69 | <0.001* |
| Body Weight (g) | 27.49 ± 2.14 | 28.14 ± 2.98 | 0.6484 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.366 ± 0.074 | 0.332 ± 0.028 | 0.3147 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.61 ± 1.37 | 14.33 ± 2.47 | 0.5125 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.60 ± 5.31 | 53.67 ± 3.65 | 0.2728 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.26 ± 0.16 | 1.36 ± 0.12 | 0.1950 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 28.20 ± 3.69 | 24.07 ± 1.50 | 0.0226* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.40 ± 5.31 | 46.33 ± 3.65 | 0.2728 |
| Trabecular Number (Tb.N) (#/mm) | 2.80 ± 0.24 | 2.62 ± 0.33 | 0.2766 |
| Trabecular Spacing (Tb.Sp) (µm) | 313.32 ± 30.86 | 335.49 ± 51.61 | 0.3460 |
| Trabecular Thickness (Tb.Th) (µm) | 47.04 ± 2.35 | 53.94 ± 3.27 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.93 ± 1.89 | 6.46 ± 1.34 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 7.66 ± 0.89 | 2.86 ± 1.11 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.00 ± 1.80 | 4.02 ± 1.21 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 86.91 ± 3.57 | 84.28 ± 4.43 | 0.2570 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 49.00 ± 6.11 | 40.64 ± 7.14 | 0.0403* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.00 ± 6.11 | 59.36 ± 7.14 | 0.0403* |