Skeletal Phenotyping of Ppp1r26 Knockout Mice

ROSSA-20260926-A60E

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Ppp1r26 KO Male M 12wk
B6N(Cg)-Ppp1r26<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Ppp1r26 KO Female F 12wk
B6N(Cg)-Ppp1r26<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Ppp1r26 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Ppp1r26 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Ppp1r26 WT Male (Mean ± SD) Ppp1r26 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 25.21 ± 1.36 25.57 ± 1.48 0.6509
Bone Mineral Density (mg/ccm HA) 1,141.76 ± 5.88 1,138.23 ± 12.49 0.5095
Cortical Area (mm^2) 0.733 ± 0.075 0.731 ± 0.046 0.9489
Cortical Area / Total Area (%) 40.84 ± 1.10 39.88 ± 1.23 0.1453
Cortical Mask (dimensionless) 0.735 ± 0.075 0.733 ± 0.046 0.9577
Cortical Porosity (%) 0.267 ± 0.031 0.32 ± 0.11 0.2393
Cortical Thickness (mm) 0.164 ± 0.010 0.1619 ± 0.0064 0.6415
Endocortical Perimeter (mm) 3.65 ± 0.20 3.72 ± 0.13 0.4430
Length (mm) 14.75 ± 0.29 15.01 ± 0.27 0.0908
Marrow Area (mm^2) 1.06 ± 0.12 1.100 ± 0.075 0.4664
Maximum Distance from Centroid (mm) 1.94 ± 0.12 1.935 ± 0.040 0.8764
Maximum Moment of Inertia (mm^4) 0.242 ± 0.048 0.241 ± 0.025 0.9754
Minimum Distance from Centroid (mm) 1.249 ± 0.079 1.275 ± 0.057 0.4827
Minimum Moment of Inertia (mm^4) 0.119 ± 0.025 0.124 ± 0.018 0.6883
Periosteal Perimeter (mm) 4.68 ± 0.38 4.83 ± 0.26 0.4023
Polar Moment of Inertia (mm^4) 0.361 ± 0.073 0.365 ± 0.042 0.8983
Pore Area (mm^2) 0.0020 ± 0.0004 0.0023 ± 0.0008 0.2880
Section Modulus about Maximum Moment of Inertia (mm^3) 0.247 ± 0.035 0.249 ± 0.022 0.8984
Section Modulus about Minimum Moment of Inertia (mm^3) 0.189 ± 0.028 0.193 ± 0.019 0.7353
Tissue Mineral Density (mg/ccm HA) 1,202.34 ± 6.26 1,199.73 ± 13.55 0.6509
Total Area (mm^2) 1.80 ± 0.19 1.83 ± 0.11 0.6574