Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Gpnmb KO Male
M
12wk
B6N(Cg)-Gpnmb tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Gpnmb KO Female
F
12wk
B6N(Cg)-Gpnmb tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Gpnmb WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Gpnmb WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Gpnmb WT Male (Mean ± SD) | Gpnmb KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 72.37 ± 2.81 | 53.14 ± 7.10 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 27.90 ± 5.99 | 28.83 ± 4.73 | 0.7613 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 44.86 ± 6.54 | 24.18 ± 3.21 | <0.001* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 2.89 ± 1.56 | 3.06 ± 0.94 | 0.8190 |
| Body Weight (g) | 23.90 ± 1.25 | 25.49 ± 1.76 | 0.0706 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.271 ± 0.068 | 0.387 ± 0.063 | 0.0071* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.70 ± 1.62 | 11.50 ± 0.50 | 0.2469 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 38.35 ± 7.94 | 54.30 ± 3.52 | <0.001* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.49 ± 0.15 | 1.43 ± 0.11 | 0.4662 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 19.05 ± 4.45 | 26.04 ± 3.13 | 0.0057* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 61.65 ± 7.94 | 45.70 ± 3.52 | <0.001* |
| Trabecular Number (Tb.N) (#/mm) | 2.43 ± 0.24 | 2.35 ± 0.15 | 0.4781 |
| Trabecular Spacing (Tb.Sp) (µm) | 373.91 ± 39.02 | 381.73 ± 25.75 | 0.6812 |
| Trabecular Thickness (Tb.Th) (µm) | 43.41 ± 4.15 | 48.37 ± 3.35 | 0.0277* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 21.88 ± 3.90 | 16.03 ± 0.91 | 0.0050* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 6.26 ± 1.96 | 6.51 ± 1.38 | 0.7934 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 15.34 ± 3.58 | 9.42 ± 1.46 | 0.0016* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 76.66 ± 3.96 | 80.65 ± 2.83 | 0.0482* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 28.79 ± 7.13 | 40.83 ± 8.16 | 0.0146* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 71.21 ± 7.13 | 59.17 ± 8.16 | 0.0146* |