Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Dnajb7 KO Male
M
12wk
B6N(Cg)-Dnajb7 tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Dnajb7 KO Female
F
12wk
B6N(Cg)-Dnajb7 tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Dnajb7 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Dnajb7 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Dnajb7 WT Male (Mean ± SD) | Dnajb7 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 14.43 ± 5.62 | 69.56 ± 3.14 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 8.56 ± 3.61 | 29.87 ± 2.86 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 7.72 ± 1.83 | 38.79 ± 0.29 | <0.001* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 1.90 ± 1.17 | 2.55 ± 0.71 | 0.4481 |
| Body Weight (g) | 26.55 ± 1.35 | 23.67 ± 2.42 | 0.0366* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.263 ± 0.075 | 0.282 ± 0.041 | 0.7167 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 11.77 ± 2.04 | 5.47 ± 1.21 | <0.001* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 49.71 ± 7.02 | 43.43 ± 2.24 | 0.2021 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.21 ± 0.19 | 1.243 ± 0.054 | 0.7862 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 21.54 ± 3.93 | 21.42 ± 0.56 | 0.9394 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 50.29 ± 7.02 | 56.57 ± 2.24 | 0.2021 |
| Trabecular Number (Tb.N) (#/mm) | 2.69 ± 0.33 | 1.70 ± 0.25 | <0.001* |
| Trabecular Spacing (Tb.Sp) (µm) | 336.93 ± 50.77 | 586.19 ± 98.99 | 0.0170* |
| Trabecular Thickness (Tb.Th) (µm) | 43.64 ± 4.49 | 31.94 ± 2.96 | 0.0015* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 28.37 ± 2.94 | 14.27 ± 2.46 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 10.49 ± 2.34 | 5.83 ± 2.12 | 0.0235* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 17.88 ± 1.14 | 11.63 ± 2.52 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 70.05 ± 9.48 | 68.86 ± 7.61 | 0.8466 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 36.20 ± 5.11 | 33.02 ± 3.89 | 0.4010 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 63.80 ± 5.11 | 66.98 ± 3.89 | 0.4010 |