Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Mfsd10 KO Male
M
12wk
B6N(Cg)-Mfsd10<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Mfsd10 KO Female
F
12wk
B6N(Cg)-Mfsd10<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Mfsd10 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Mfsd10 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Mfsd10 WT Male (Mean ± SD) | Mfsd10 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 71.13 ± 3.32 | 61.27 ± 4.68 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 35.83 ± 3.96 | 30.33 ± 2.73 | 0.0114* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 35.50 ± 3.17 | 31.06 ± 4.91 | 0.0792 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.43 ± 0.46 | 2.18 ± 0.44 | <0.001* |
| Body Weight (g) | 26.07 ± 1.17 | 26.47 ± 0.99 | 0.4982 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.356 ± 0.051 | 0.319 ± 0.048 | 0.1882 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.59 ± 1.19 | 14.31 ± 3.30 | 0.6052 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 50.05 ± 4.47 | 49.51 ± 5.36 | 0.8464 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.40 ± 0.12 | 1.30 ± 0.13 | 0.1430 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 25.47 ± 2.95 | 24.37 ± 2.54 | 0.4647 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 49.95 ± 4.47 | 50.49 ± 5.36 | 0.8464 |
| Trabecular Number (Tb.N) (#/mm) | 2.60 ± 0.21 | 2.69 ± 0.42 | 0.6372 |
| Trabecular Spacing (Tb.Sp) (µm) | 337.36 ± 33.43 | 329.52 ± 52.85 | 0.7514 |
| Trabecular Thickness (Tb.Th) (µm) | 51.15 ± 1.63 | 55.09 ± 6.10 | 0.1370 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.63 ± 1.77 | 10.25 ± 1.74 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 6.11 ± 1.25 | 4.09 ± 0.99 | 0.0048* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 9.84 ± 1.94 | 6.07 ± 2.02 | 0.0032* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 81.26 ± 4.16 | 87.92 ± 5.60 | 0.0242* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 38.57 ± 6.61 | 40.93 ± 6.73 | 0.5202 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 61.43 ± 6.61 | 59.07 ± 6.73 | 0.5202 |