Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Ptpru KO Male
M
12wk
B6N(Cg)-Ptpru<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Ptpru KO Female
F
12wk
B6N(Cg)-Ptpru<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Ptpru WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Ptpru WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Ptpru WT Male (Mean ± SD) | Ptpru KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 50.60 ± 5.88 | 71.06 ± 4.94 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.00 ± 4.87 | 36.66 ± 5.04 | 0.0154* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 22.01 ± 3.66 | 34.02 ± 4.28 | <0.001* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.46 ± 0.48 | 5.09 ± 0.97 | 0.0018* |
| Body Weight (g) | 27.49 ± 2.14 | 24.20 ± 2.14 | 0.0122* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.366 ± 0.074 | 0.391 ± 0.056 | 0.5150 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.61 ± 1.37 | 15.31 ± 1.82 | 0.0679 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.60 ± 5.31 | 51.81 ± 5.20 | 0.1246 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.26 ± 0.16 | 1.43 ± 0.14 | 0.0628 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 28.20 ± 3.69 | 27.70 ± 2.79 | 0.7877 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.40 ± 5.31 | 48.19 ± 5.20 | 0.1246 |
| Trabecular Number (Tb.N) (#/mm) | 2.80 ± 0.24 | 2.94 ± 0.40 | 0.4222 |
| Trabecular Spacing (Tb.Sp) (µm) | 313.32 ± 30.86 | 293.74 ± 46.48 | 0.3689 |
| Trabecular Thickness (Tb.Th) (µm) | 47.04 ± 2.35 | 54.37 ± 3.53 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.93 ± 1.89 | 24.75 ± 3.74 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 7.66 ± 0.89 | 9.67 ± 1.94 | 0.0302* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.00 ± 1.80 | 15.60 ± 3.04 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 86.91 ± 3.57 | 77.49 ± 6.91 | 0.0064* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 49.00 ± 6.11 | 38.70 ± 6.33 | 0.0106* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.00 ± 6.11 | 61.30 ± 6.33 | 0.0106* |