Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Tspan18 KO Male
M
12wk
B6N(Cg)-Tspan18<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Tspan18 KO Female
F
12wk
B6N(Cg)-Tspan18<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Tspan18 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Tspan18 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Tspan18 WT Male (Mean ± SD) | Tspan18 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 48.34 ± 6.60 | 72.07 ± 3.40 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 27.33 ± 3.95 | 42.95 ± 3.08 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 22.50 ± 3.62 | 29.95 ± 2.39 | <0.001* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.23 ± 1.41 | 4.98 ± 1.01 | 0.0186* |
| Body Weight (g) | 21.37 ± 2.19 | 21.70 ± 1.58 | 0.7486 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.415 ± 0.065 | 0.723 ± 0.059 | <0.001* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 9.06 ± 1.36 | 15.04 ± 2.49 | <0.001* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 54.73 ± 3.77 | 58.92 ± 2.67 | 0.0310* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.52 ± 0.25 | 2.15 ± 0.16 | <0.001* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 27.05 ± 3.01 | 33.41 ± 2.33 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 45.27 ± 3.77 | 41.08 ± 2.67 | 0.0310* |
| Trabecular Number (Tb.N) (#/mm) | 2.10 ± 0.22 | 3.72 ± 0.43 | <0.001* |
| Trabecular Spacing (Tb.Sp) (µm) | 449.58 ± 57.33 | 234.73 ± 33.53 | <0.001* |
| Trabecular Thickness (Tb.Th) (µm) | 44.15 ± 3.15 | 38.49 ± 5.96 | 0.0433* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 21.00 ± 4.56 | 23.72 ± 2.74 | 0.1976 |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 9.10 ± 2.56 | 10.71 ± 1.40 | 0.1650 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 12.26 ± 2.77 | 13.05 ± 1.91 | 0.5451 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 78.38 ± 4.16 | 82.53 ± 4.39 | 0.0909 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 42.76 ± 5.84 | 45.20 ± 2.68 | 0.3389 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 57.24 ± 5.84 | 54.80 ± 2.68 | 0.3389 |