Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Glycam1 KO Male
M
12wk
B6N(Cg)-Glycam1 tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Glycam1 KO Female
F
12wk
B6N(Cg)-Glycam1 tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Glycam1 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Glycam1 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Glycam1 WT Male (Mean ± SD) | Glycam1 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 60.29 ± 4.51 | 59.93 ± 6.37 | 0.9070 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 27.86 ± 3.44 | 27.93 ± 2.35 | 0.9652 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 34.61 ± 3.71 | 31.50 ± 6.24 | 0.2769 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 4.01 ± 0.83 | 2.28 ± 0.42 | <0.001* |
| Body Weight (g) | 26.54 ± 1.53 | 24.90 ± 1.15 | 0.0396* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.301 ± 0.039 | 0.327 ± 0.033 | 0.2231 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.22 ± 2.53 | 11.28 ± 0.97 | 0.3321 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 44.53 ± 3.76 | 47.32 ± 4.27 | 0.2159 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.42 ± 0.14 | 1.33 ± 0.15 | 0.2539 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 21.39 ± 2.38 | 23.44 ± 2.02 | 0.1039 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 55.47 ± 3.76 | 52.68 ± 4.27 | 0.2159 |
| Trabecular Number (Tb.N) (#/mm) | 2.38 ± 0.30 | 4.16 ± 0.59 | <0.001* |
| Trabecular Spacing (Tb.Sp) (µm) | 386.73 ± 55.78 | 220.34 ± 35.23 | <0.001* |
| Trabecular Thickness (Tb.Th) (µm) | 42.65 ± 6.61 | 27.37 ± 2.65 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 29.22 ± 1.87 | 15.99 ± 2.22 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 9.13 ± 1.11 | 5.80 ± 1.12 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 20.00 ± 1.65 | 10.06 ± 1.95 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 74.49 ± 3.85 | 80.11 ± 3.18 | 0.0100* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 31.32 ± 3.56 | 36.81 ± 4.83 | 0.0299* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 68.68 ± 3.56 | 63.19 ± 4.83 | 0.0299* |