Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Efna4 KO Male
M
12wk
B6N(Cg)-Enfa4<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Efna4 KO Female
F
12wk
B6N(Cg)-Enfa4<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Efna4 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Efna4 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Efna4 WT Male (Mean ± SD) | Efna4 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 50.60 ± 5.88 | 68.46 ± 5.26 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.00 ± 4.87 | 48.43 ± 3.57 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 22.01 ± 3.66 | 19.37 ± 2.29 | 0.1281 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.46 ± 0.48 | 5.25 ± 1.11 | 0.0020* |
| Body Weight (g) | 27.49 ± 2.14 | 23.16 ± 1.75 | 0.0010* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.366 ± 0.074 | 0.579 ± 0.062 | <0.001* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.61 ± 1.37 | 14.75 ± 2.12 | 0.2528 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.60 ± 5.31 | 71.46 ± 1.75 | <0.001* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.26 ± 0.16 | 1.50 ± 0.10 | 0.0049* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 28.20 ± 3.69 | 40.53 ± 0.92 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.40 ± 5.31 | 28.54 ± 1.75 | <0.001* |
| Trabecular Number (Tb.N) (#/mm) | 2.80 ± 0.24 | 2.82 ± 0.31 | 0.8762 |
| Trabecular Spacing (Tb.Sp) (µm) | 313.32 ± 30.86 | 308.64 ± 41.54 | 0.8143 |
| Trabecular Thickness (Tb.Th) (µm) | 47.04 ± 2.35 | 52.04 ± 2.96 | 0.0035* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.93 ± 1.89 | 12.83 ± 1.78 | 0.0069* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 7.66 ± 0.89 | 8.28 ± 2.33 | 0.5327 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.00 ± 1.80 | 4.94 ± 1.42 | 0.0050* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 86.91 ± 3.57 | 86.87 ± 1.99 | 0.9807 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 49.00 ± 6.11 | 63.30 ± 2.48 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.00 ± 6.11 | 36.70 ± 2.48 | <0.001* |