Skeletal Phenotyping of Car12 Knockout Mice

ROSSA-20260926-8B33

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Car12 KO Male M 12wk
B6N(Cg)-Car12<tm1b(KOMP)Wtsi>/J (C57BL/6NTac) • KO/KO
Car12 KO Female F 12wk
B6N(Cg)-Car12<tm1b(KOMP)Wtsi>/J (C57BL/6NTac) • KO/KO
Car12 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Car12 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Car12 WT Male (Mean ± SD) Car12 KO Male (Mean ± SD) T-test (p-Value)
Bone Mineral Density (mg/ccm HA) 1,142.87 ± 8.90 1,150.26 ± 10.21 0.1710
Cortical Area (mm^2) 0.724 ± 0.063 0.674 ± 0.043 0.1012
Cortical Area / Total Area (%) 41.21 ± 2.10 41.13 ± 2.19 0.9497
Cortical Mask (dimensionless) 0.726 ± 0.063 0.676 ± 0.043 0.1003
Cortical Porosity (%) 0.257 ± 0.042 0.248 ± 0.014 0.5719
Cortical Thickness (mm) 0.162 ± 0.011 0.1575 ± 0.0096 0.4180
Endocortical Perimeter (mm) 3.60 ± 0.12 3.477 ± 0.086 0.0514
Length (mm) 14.76 ± 0.22 14.50 ± 0.18 0.0319*
Marrow Area (mm^2) 1.031 ± 0.070 0.963 ± 0.048 0.0512
Maximum Distance from Centroid (mm) 1.951 ± 0.086 1.823 ± 0.049 0.0042*
Maximum Moment of Inertia (mm^4) 0.237 ± 0.036 0.197 ± 0.020 0.0239*
Minimum Distance from Centroid (mm) 1.219 ± 0.040 1.210 ± 0.031 0.6523
Minimum Moment of Inertia (mm^4) 0.112 ± 0.015 0.1006 ± 0.0060 0.0968
Periosteal Perimeter (mm) 4.63 ± 0.25 4.337 ± 0.086 0.0103*
Polar Moment of Inertia (mm^4) 0.349 ± 0.051 0.298 ± 0.026 0.0339*
Pore Area (mm^2) 0.0019 ± 0.0002 0.0017 ± 0.0001 0.1051
Section Modulus about Maximum Moment of Inertia (mm^3) 0.242 ± 0.027 0.216 ± 0.019 0.0562
Section Modulus about Minimum Moment of Inertia (mm^3) 0.183 ± 0.020 0.166 ± 0.011 0.0750
Tissue Mineral Density (mg/ccm HA) 1,206.23 ± 8.97 1,216.17 ± 8.72 0.0540
Total Area (mm^2) 1.76 ± 0.11 1.638 ± 0.055 0.0247*