Skeletal Phenotyping of Dnajc14 Knockout Mice

ROSSA-20260926-8AEC

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Dnajc14 KO Male M 12wk
B6N(Cg)-Dnajc14<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Dnajc14 KO Female F 12wk
B6N(Cg)-Dnajc14<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Dnajc14 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Dnajc14 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Dnajc14 WT Male (Mean ± SD) Dnajc14 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 22.00 ± 3.26 24.43 ± 1.80 0.1064
Bone Mineral Density (mg/ccm HA) 1,179.19 ± 5.92 1,164.32 ± 10.50 0.0057*
Cortical Area (mm^2) 0.728 ± 0.082 0.750 ± 0.067 0.5965
Cortical Area / Total Area (%) 41.23 ± 1.09 39.46 ± 0.91 0.0053*
Cortical Mask (dimensionless) 0.730 ± 0.082 0.752 ± 0.067 0.5950
Cortical Porosity (%) 0.279 ± 0.043 0.300 ± 0.043 0.3877
Cortical Thickness (mm) 0.165 ± 0.010 0.1626 ± 0.0082 0.6374
Endocortical Perimeter (mm) 3.60 ± 0.21 3.80 ± 0.18 0.0911
Length (mm) 14.67 ± 0.36 14.78 ± 0.29 0.5401
Marrow Area (mm^2) 1.04 ± 0.13 1.15 ± 0.11 0.0974
Maximum Distance from Centroid (mm) 1.88 ± 0.15 1.995 ± 0.092 0.1175
Maximum Moment of Inertia (mm^4) 0.227 ± 0.059 0.260 ± 0.045 0.2610
Minimum Distance from Centroid (mm) 1.274 ± 0.062 1.319 ± 0.068 0.2096
Minimum Moment of Inertia (mm^4) 0.121 ± 0.026 0.132 ± 0.025 0.4438
Periosteal Perimeter (mm) 4.60 ± 0.43 4.87 ± 0.41 0.2510
Polar Moment of Inertia (mm^4) 0.349 ± 0.084 0.392 ± 0.070 0.3107
Pore Area (mm^2) 0.0021 ± 0.0005 0.0023 ± 0.0004 0.4427
Section Modulus about Maximum Moment of Inertia (mm^3) 0.238 ± 0.042 0.259 ± 0.034 0.3171
Section Modulus about Minimum Moment of Inertia (mm^3) 0.189 ± 0.031 0.199 ± 0.028 0.5517
Tissue Mineral Density (mg/ccm HA) 1,249.02 ± 9.28 1,232.95 ± 11.51 0.0122*
Total Area (mm^2) 1.77 ± 0.20 1.90 ± 0.17 0.2080