Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Dnajb3 KO Male
M
12wk
B6N(Cg)-Dnajb3 tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Dnajb3 KO Female
F
12wk
B6N(Cg)-Dnajb3 tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Dnajb3 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Dnajb3 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Dnajb3 WT Male (Mean ± SD) | Dnajb3 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 60.29 ± 4.51 | 65.78 ± 2.94 | 0.0237* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 27.86 ± 3.44 | 33.93 ± 2.60 | 0.0058* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 34.61 ± 3.71 | 33.21 ± 1.83 | 0.4476 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 4.01 ± 0.83 | 4.90 ± 1.35 | 0.2066 |
| Body Weight (g) | 26.54 ± 1.53 | 24.96 ± 3.29 | 0.2769 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.301 ± 0.039 | 0.324 ± 0.041 | 0.3084 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.22 ± 2.53 | 10.89 ± 1.26 | 0.5637 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 44.53 ± 3.76 | 50.45 ± 3.08 | 0.0131* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.42 ± 0.14 | 1.277 ± 0.095 | 0.0524 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 21.39 ± 2.38 | 26.00 ± 2.16 | 0.0030* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 55.47 ± 3.76 | 49.55 ± 3.08 | 0.0131* |
| Trabecular Number (Tb.N) (#/mm) | 2.38 ± 0.30 | 2.26 ± 0.27 | 0.4483 |
| Trabecular Spacing (Tb.Sp) (µm) | 386.73 ± 55.78 | 403.78 ± 45.78 | 0.5606 |
| Trabecular Thickness (Tb.Th) (µm) | 42.65 ± 6.61 | 48.31 ± 2.19 | 0.0627 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 29.22 ± 1.87 | 22.05 ± 4.10 | 0.0012* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 9.13 ± 1.11 | 9.60 ± 2.30 | 0.6414 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 20.00 ± 1.65 | 12.17 ± 2.07 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 74.49 ± 3.85 | 77.80 ± 5.01 | 0.2022 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 31.32 ± 3.56 | 44.06 ± 4.40 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 68.68 ± 3.56 | 55.94 ± 4.40 | <0.001* |