Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Dnaja4 KO Male
M
12wk
B6N(Cg)-Dnaja4<tm1b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Dnaja4 KO Female
F
12wk
B6N(Cg)-Dnaja4<tm1b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Dnaja4 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Dnaja4 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Dnaja4 WT Male (Mean ± SD) | Dnaja4 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 50.60 ± 5.88 | 64.73 ± 6.63 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.00 ± 4.87 | 47.61 ± 5.31 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 22.01 ± 3.66 | 17.68 ± 1.94 | 0.0152* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.46 ± 0.48 | 4.13 ± 0.95 | 0.1261 |
| Body Weight (g) | 27.49 ± 2.14 | 27.26 ± 1.83 | 0.8304 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.366 ± 0.074 | 0.619 ± 0.084 | <0.001* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.61 ± 1.37 | 16.95 ± 1.65 | 0.0010* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.60 ± 5.31 | 72.86 ± 2.68 | <0.001* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.26 ± 0.16 | 1.50 ± 0.10 | 0.0042* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 28.20 ± 3.69 | 40.84 ± 2.41 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.40 ± 5.31 | 27.14 ± 2.68 | <0.001* |
| Trabecular Number (Tb.N) (#/mm) | 2.80 ± 0.24 | 2.98 ± 0.26 | 0.1934 |
| Trabecular Spacing (Tb.Sp) (µm) | 313.32 ± 30.86 | 282.25 ± 27.77 | 0.0677 |
| Trabecular Thickness (Tb.Th) (µm) | 47.04 ± 2.35 | 57.07 ± 3.02 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.93 ± 1.89 | 11.05 ± 3.88 | 0.0098* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 7.66 ± 0.89 | 6.62 ± 2.25 | 0.2801 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.00 ± 1.80 | 3.13 ± 1.17 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 86.91 ± 3.57 | 87.20 ± 3.19 | 0.8753 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 49.00 ± 6.11 | 68.59 ± 3.40 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.00 ± 6.11 | 31.41 ± 3.40 | <0.001* |