Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Hspb3 KO Male
M
12wk
B6N(Cg)-Hspb3<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Hspb3 KO Female
F
12wk
B6N(Cg)-Hspb3<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Hspb3 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Hspb3 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Hspb3 WT Male (Mean ± SD) | Hspb3 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 59.29 ± 6.90 | 68.11 ± 5.92 | 0.0224* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 32.58 ± 1.62 | 38.71 ± 5.15 | 0.0108* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 26.59 ± 3.40 | 30.59 ± 5.03 | 0.1130 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 4.02 ± 1.23 | 5.47 ± 1.17 | 0.0580 |
| Body Weight (g) | 20.78 ± 2.86 | 19.14 ± 2.35 | 0.2601 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.425 ± 0.081 | 0.66 ± 0.14 | 0.0024* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 8.76 ± 1.94 | 7.89 ± 2.59 | 0.4911 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 55.10 ± 2.80 | 55.86 ± 5.65 | 0.7575 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.59 ± 0.23 | 2.18 ± 0.21 | <0.001* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 27.70 ± 1.84 | 30.39 ± 3.70 | 0.1065 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 44.90 ± 2.80 | 44.14 ± 5.65 | 0.7575 |
| Trabecular Number (Tb.N) (#/mm) | 2.00 ± 0.31 | 3.05 ± 0.53 | <0.001* |
| Trabecular Spacing (Tb.Sp) (µm) | 475.99 ± 85.64 | 321.16 ± 74.98 | 0.0029* |
| Trabecular Thickness (Tb.Th) (µm) | 44.83 ± 4.43 | 25.99 ± 5.60 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 23.77 ± 6.21 | 23.76 ± 1.81 | 0.9970 |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 10.19 ± 2.47 | 9.83 ± 2.03 | 0.7808 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 13.56 ± 3.98 | 13.95 ± 2.44 | 0.8338 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 81.90 ± 6.53 | 74.07 ± 4.45 | 0.0240* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 43.45 ± 2.82 | 41.39 ± 7.50 | 0.5347 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 56.55 ± 2.82 | 58.61 ± 7.50 | 0.5347 |