Skeletal Phenotyping of Espnl Knockout Mice

ROSSA-20260926-7F95

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Espnl KO Male M 12wk
B6N(Cg)-Espnl<tm1b(KOMP)Wtsi>/2J (C57BL/6NTac) • KO/KO
Espnl KO Female F 12wk
B6N(Cg)-Espnl<tm1b(KOMP)Wtsi>/2J (C57BL/6NTac) • KO/KO
Espnl WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Espnl WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Espnl WT Male (Mean ± SD) Espnl KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 24.87 ± 2.15 22.65 ± 3.37 0.1647
Bone Mineral Density (mg/ccm HA) 1,150.63 ± 12.21 1,149.98 ± 9.01 0.9111
Cortical Area (mm^2) 0.760 ± 0.090 0.670 ± 0.091 0.0845
Cortical Area / Total Area (%) 40.37 ± 1.94 39.85 ± 2.70 0.6813
Cortical Mask (dimensionless) 0.762 ± 0.091 0.672 ± 0.092 0.0855
Cortical Porosity (%) 0.284 ± 0.040 0.302 ± 0.051 0.4837
Cortical Thickness (mm) 0.168 ± 0.011 0.155 ± 0.017 0.1317
Endocortical Perimeter (mm) 3.75 ± 0.31 3.55 ± 0.12 0.1397
Length (mm) 14.91 ± 0.33 14.62 ± 0.29 0.1053
Marrow Area (mm^2) 1.13 ± 0.19 1.003 ± 0.068 0.1349
Maximum Distance from Centroid (mm) 1.96 ± 0.17 1.86 ± 0.10 0.2132
Maximum Moment of Inertia (mm^4) 0.258 ± 0.070 0.202 ± 0.040 0.0901
Minimum Distance from Centroid (mm) 1.32 ± 0.10 1.236 ± 0.071 0.1042
Minimum Moment of Inertia (mm^4) 0.137 ± 0.037 0.104 ± 0.022 0.0681
Periosteal Perimeter (mm) 4.90 ± 0.54 4.44 ± 0.26 0.0642
Polar Moment of Inertia (mm^4) 0.39 ± 0.11 0.306 ± 0.061 0.0803
Pore Area (mm^2) 0.0022 ± 0.0004 0.0021 ± 0.0006 0.7020
Section Modulus about Maximum Moment of Inertia (mm^3) 0.259 ± 0.048 0.216 ± 0.031 0.0637
Section Modulus about Minimum Moment of Inertia (mm^3) 0.204 ± 0.040 0.167 ± 0.026 0.0579
Tissue Mineral Density (mg/ccm HA) 1,214.53 ± 10.99 1,219.22 ± 6.17 0.3416
Total Area (mm^2) 1.89 ± 0.27 1.68 ± 0.14 0.0866