Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Rab3c KO Male
M
12wk
B6N(Cg)-Rab3c<tm1b(EUCOMM)Wtsi>/J (C57BL/6NTac)
• KO/KO
Rab3c KO Female
F
12wk
B6N(Cg)-Rab3c<tm1b(EUCOMM)Wtsi>/J (C57BL/6NTac)
• KO/KO
Rab3c WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Rab3c WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Rab3c WT Male (Mean ± SD) | Rab3c KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 50.60 ± 5.88 | 44.77 ± 5.72 | 0.0811 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.00 ± 4.87 | 20.83 ± 3.40 | 0.0027* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 22.01 ± 3.66 | 24.07 ± 3.48 | 0.2976 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.46 ± 0.48 | 2.00 ± 0.55 | <0.001* |
| Body Weight (g) | 27.49 ± 2.14 | 24.71 ± 1.51 | 0.0141* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.366 ± 0.074 | 0.320 ± 0.033 | 0.1615 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.61 ± 1.37 | 12.02 ± 1.64 | 0.0699 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.60 ± 5.31 | 46.25 ± 3.05 | <0.001* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.26 ± 0.16 | 1.55 ± 0.14 | 0.0025* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 28.20 ± 3.69 | 20.61 ± 2.31 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.40 ± 5.31 | 53.75 ± 3.05 | <0.001* |
| Trabecular Number (Tb.N) (#/mm) | 2.80 ± 0.24 | 2.37 ± 0.33 | 0.0134* |
| Trabecular Spacing (Tb.Sp) (µm) | 313.32 ± 30.86 | 384.02 ± 64.63 | 0.0205* |
| Trabecular Thickness (Tb.Th) (µm) | 47.04 ± 2.35 | 51.97 ± 4.17 | 0.0164* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.93 ± 1.89 | 15.98 ± 2.40 | 0.9605 |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 7.66 ± 0.89 | 5.13 ± 1.22 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.00 ± 1.80 | 11.50 ± 1.59 | 0.0017* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 86.91 ± 3.57 | 77.16 ± 5.69 | 0.0018* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 49.00 ± 6.11 | 30.59 ± 5.33 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.00 ± 6.11 | 69.41 ± 5.33 | <0.001* |