Skeletal Phenotyping of Ttll6 Knockout Mice

ROSSA-20260926-7C92

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Ttll6 KO Male M 12wk
B6N(Cg)-Ttll6<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Ttll6 KO Female F 12wk
B6N(Cg)-Ttll6<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Ttll6 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Ttll6 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Ttll6 WT Male (Mean ± SD) Ttll6 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 25.97 ± 1.58 23.66 ± 0.90 0.0073*
Bone Mineral Density (mg/ccm HA) 1,153.01 ± 15.24 1,160.62 ± 7.59 0.2566
Cortical Area (mm^2) 0.791 ± 0.097 0.752 ± 0.048 0.3633
Cortical Area / Total Area (%) 40.44 ± 2.56 42.05 ± 1.77 0.1939
Cortical Mask (dimensionless) 0.793 ± 0.097 0.754 ± 0.049 0.3617
Cortical Porosity (%) 0.283 ± 0.037 0.262 ± 0.030 0.2531
Cortical Thickness (mm) 0.170 ± 0.017 0.1706 ± 0.0096 0.9755
Endocortical Perimeter (mm) 3.82 ± 0.26 3.61 ± 0.16 0.0948
Length (mm) 15.05 ± 0.31 14.82 ± 0.21 0.1190
Marrow Area (mm^2) 1.17 ± 0.16 1.038 ± 0.094 0.0927
Maximum Distance from Centroid (mm) 2.03 ± 0.12 1.928 ± 0.080 0.0954
Maximum Moment of Inertia (mm^4) 0.281 ± 0.061 0.241 ± 0.028 0.1500
Minimum Distance from Centroid (mm) 1.33 ± 0.10 1.272 ± 0.067 0.2633
Minimum Moment of Inertia (mm^4) 0.144 ± 0.036 0.122 ± 0.020 0.1731
Periosteal Perimeter (mm) 5.08 ± 0.46 4.68 ± 0.26 0.0598
Polar Moment of Inertia (mm^4) 0.425 ± 0.096 0.363 ± 0.047 0.1495
Pore Area (mm^2) 0.0023 ± 0.0004 0.0020 ± 0.0003 0.1817
Section Modulus about Maximum Moment of Inertia (mm^3) 0.275 ± 0.045 0.250 ± 0.020 0.2047
Section Modulus about Minimum Moment of Inertia (mm^3) 0.215 ± 0.038 0.191 ± 0.021 0.1660
Tissue Mineral Density (mg/ccm HA) 1,215.47 ± 12.78 1,224.55 ± 8.99 0.1464
Total Area (mm^2) 1.96 ± 0.24 1.79 ± 0.13 0.1283