Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
C1qb KO Male
M
12wk
B6N(Cg)-C1qb<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
C1qb KO Female
F
12wk
B6N(Cg)-C1qb<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
C1qb WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
C1qb WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | C1qb WT Male (Mean ± SD) | C1qb KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 71.13 ± 3.32 | 72.52 ± 7.25 | 0.6516 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 35.83 ± 3.96 | 52.63 ± 6.46 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 35.50 ± 3.17 | 20.74 ± 4.06 | <0.001* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.43 ± 0.46 | 9.00 ± 1.78 | <0.001* |
| Body Weight (g) | 26.07 ± 1.17 | 25.85 ± 1.51 | 0.7670 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.356 ± 0.051 | 0.55 ± 0.10 | <0.001* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.59 ± 1.19 | 17.78 ± 1.53 | <0.001* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 50.05 ± 4.47 | 71.75 ± 4.30 | <0.001* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.40 ± 0.12 | 1.31 ± 0.17 | 0.2624 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 25.47 ± 2.95 | 40.77 ± 3.23 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 49.95 ± 4.47 | 28.25 ± 4.30 | <0.001* |
| Trabecular Number (Tb.N) (#/mm) | 2.60 ± 0.21 | 3.03 ± 0.21 | 0.0026* |
| Trabecular Spacing (Tb.Sp) (µm) | 337.36 ± 33.43 | 274.61 ± 23.79 | 0.0020* |
| Trabecular Thickness (Tb.Th) (µm) | 51.15 ± 1.63 | 58.60 ± 3.56 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.63 ± 1.77 | 22.49 ± 2.10 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 6.11 ± 1.25 | 13.71 ± 1.56 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 9.84 ± 1.94 | 8.07 ± 1.43 | 0.0728 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 81.26 ± 4.16 | 85.94 ± 4.09 | 0.0522 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 38.57 ± 6.61 | 62.97 ± 5.32 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 61.43 ± 6.61 | 37.03 ± 5.32 | <0.001* |