Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Ypel1 KO Male
M
12wk
B6N(Cg)-Ypel1<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Ypel1 KO Female
F
12wk
B6N(Cg)-Ypel1<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Ypel1 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Ypel1 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Ypel1 WT Male (Mean ± SD) | Ypel1 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 55.31 ± 8.10 | 81.04 ± 3.81 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.62 ± 3.72 | 59.71 ± 6.55 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 25.28 ± 7.84 | 21.91 ± 2.88 | 0.3532 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 5.02 ± 1.08 | 2.73 ± 1.16 | 0.0065* |
| Body Weight (g) | 25.33 ± 1.81 | 23.41 ± 4.01 | 0.2688 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.415 ± 0.049 | 0.708 ± 0.086 | <0.001* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 11.88 ± 1.17 | 16.01 ± 2.51 | 0.0015* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 54.91 ± 8.95 | 72.91 ± 4.93 | 0.0010* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.45 ± 0.13 | 1.67 ± 0.19 | 0.0249* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 28.46 ± 3.84 | 43.20 ± 4.58 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 45.09 ± 8.95 | 27.09 ± 4.93 | 0.0010* |
| Trabecular Number (Tb.N) (#/mm) | 2.40 ± 0.24 | 2.77 ± 0.28 | 0.0186* |
| Trabecular Spacing (Tb.Sp) (µm) | 375.20 ± 45.30 | 309.80 ± 41.29 | 0.0135* |
| Trabecular Thickness (Tb.Th) (µm) | 49.36 ± 4.29 | 56.31 ± 4.39 | 0.0096* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 23.11 ± 3.69 | 4.47 ± 2.31 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 11.39 ± 1.02 | 3.52 ± 1.61 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 12.72 ± 2.62 | 1.36 ± 0.61 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 78.25 ± 4.41 | 87.64 ± 2.61 | <0.001* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 47.73 ± 6.00 | 71.31 ± 6.37 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 52.27 ± 6.00 | 28.69 ± 6.37 | <0.001* |