Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Il24 KO Male
M
12wk
B6N(Cg)-Il24<tm1.1(KOMP)Vlcg>/2J (C57BL/6NTac)
• KO/KO
Il24 KO Female
F
12wk
B6N(Cg)-Il24<tm1.1(KOMP)Vlcg>/2J (C57BL/6NTac)
• KO/KO
Il24 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Il24 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Il24 WT Male (Mean ± SD) | Il24 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 49.64 ± 8.50 | 64.91 ± 3.33 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.02 ± 4.95 | 27.39 ± 1.93 | 0.4377 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 23.28 ± 4.41 | 37.65 ± 3.28 | <0.001* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.91 ± 0.57 | 3.06 ± 0.80 | 0.0628 |
| Body Weight (g) | 20.78 ± 2.18 | 24.82 ± 1.20 | <0.001* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.451 ± 0.081 | 0.391 ± 0.054 | 0.1361 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 7.23 ± 1.32 | 16.26 ± 3.78 | <0.001* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 55.67 ± 4.10 | 42.20 ± 3.31 | <0.001* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.67 ± 0.23 | 1.90 ± 0.31 | 0.1228 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 27.61 ± 2.38 | 21.19 ± 1.85 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 44.33 ± 4.10 | 57.80 ± 3.31 | <0.001* |
| Trabecular Number (Tb.N) (#/mm) | 1.68 ± 0.33 | 4.01 ± 0.52 | <0.001* |
| Trabecular Spacing (Tb.Sp) (µm) | 593.42 ± 161.68 | 215.33 ± 36.34 | <0.001* |
| Trabecular Thickness (Tb.Th) (µm) | 42.45 ± 5.24 | 40.28 ± 5.39 | 0.4580 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 23.06 ± 1.99 | 20.79 ± 1.72 | 0.0462* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 10.58 ± 0.77 | 6.62 ± 0.84 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 12.71 ± 2.61 | 14.66 ± 1.14 | 0.1657 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 81.17 ± 2.42 | 79.94 ± 4.07 | 0.5245 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 46.07 ± 6.16 | 31.35 ± 3.36 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 53.93 ± 6.16 | 68.65 ± 3.36 | <0.001* |