Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Slc46a3 KO Male
M
12wk
B6N(Cg)-Slc46a3<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Slc46a3 KO Female
F
12wk
B6N(Cg)-Slc46a3<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Slc46a3 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Slc46a3 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Slc46a3 WT Male (Mean ± SD) | Slc46a3 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 59.54 ± 16.48 | 51.46 ± 3.68 | 0.2259 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.85 ± 11.05 | 32.12 ± 3.23 | 0.6145 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 33.91 ± 4.02 | 20.31 ± 3.46 | <0.001* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.11 ± 1.20 | 1.60 ± 1.04 | 0.0297* |
| Body Weight (g) | 26.57 ± 2.43 | 26.87 ± 1.55 | 0.7825 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.32 ± 0.11 | 0.428 ± 0.073 | 0.0563 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 14.07 ± 3.92 | 17.05 ± 2.84 | 0.1262 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 44.89 ± 9.40 | 61.35 ± 4.21 | 0.0011* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.32 ± 0.13 | 1.32 ± 0.10 | 0.9803 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 22.65 ± 5.63 | 31.20 ± 2.72 | 0.0028* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 55.11 ± 9.40 | 38.66 ± 4.21 | 0.0011* |
| Trabecular Number (Tb.N) (#/mm) | 2.76 ± 0.54 | 2.97 ± 0.40 | 0.4207 |
| Trabecular Spacing (Tb.Sp) (µm) | 329.19 ± 74.66 | 288.61 ± 52.48 | 0.2591 |
| Trabecular Thickness (Tb.Th) (µm) | 49.91 ± 5.91 | 57.08 ± 5.76 | 0.0374* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 16.34 ± 5.50 | 4.50 ± 2.17 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 5.66 ± 2.72 | 2.47 ± 1.55 | 0.0174* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 10.56 ± 3.74 | 1.81 ± 0.94 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 81.09 ± 4.20 | 81.52 ± 4.06 | 0.8499 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 33.71 ± 8.56 | 60.64 ± 10.06 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 66.29 ± 8.56 | 41.88 ± 7.00 | <0.001* |