Skeletal Phenotyping of Ifnk Knockout Mice

ROSSA-20260926-6E68

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Ifnk KO Male M 12wk
B6N(Cg)-Ifnk<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Ifnk KO Female F 12wk
B6N(Cg)-Ifnk<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Ifnk WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Ifnk WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Ifnk WT Male (Mean ± SD) Ifnk KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 28.21 ± 2.11 26.03 ± 1.31 0.0354*
Bone Mineral Density (mg/ccm HA) 1,135.37 ± 9.56 1,152.52 ± 11.72 0.0096*
Cortical Area (mm^2) 0.685 ± 0.059 0.760 ± 0.055 0.0277*
Cortical Area / Total Area (%) 38.71 ± 1.21 42.23 ± 1.71 <0.001*
Cortical Mask (dimensionless) 0.687 ± 0.059 0.762 ± 0.055 0.0275*
Cortical Porosity (%) 0.249 ± 0.026 0.262 ± 0.034 0.4423
Cortical Thickness (mm) 0.154 ± 0.011 0.170 ± 0.012 0.0208*
Endocortical Perimeter (mm) 3.69 ± 0.14 3.61 ± 0.11 0.2681
Length (mm) 14.74 ± 0.22 14.99 ± 0.23 0.0516
Marrow Area (mm^2) 1.083 ± 0.081 1.038 ± 0.065 0.2658
Maximum Distance from Centroid (mm) 1.912 ± 0.090 1.960 ± 0.082 0.3158
Maximum Moment of Inertia (mm^4) 0.225 ± 0.038 0.252 ± 0.036 0.1998
Minimum Distance from Centroid (mm) 1.244 ± 0.046 1.235 ± 0.041 0.7120
Minimum Moment of Inertia (mm^4) 0.112 ± 0.016 0.120 ± 0.013 0.3180
Periosteal Perimeter (mm) 4.67 ± 0.29 4.74 ± 0.23 0.6336
Polar Moment of Inertia (mm^4) 0.337 ± 0.054 0.371 ± 0.047 0.2213
Pore Area (mm^2) 0.0017 ± 0.0002 0.0020 ± 0.0003 0.0523
Section Modulus about Maximum Moment of Inertia (mm^3) 0.234 ± 0.029 0.256 ± 0.027 0.1689
Section Modulus about Minimum Moment of Inertia (mm^3) 0.179 ± 0.020 0.193 ± 0.016 0.1505
Tissue Mineral Density (mg/ccm HA) 1,198.35 ± 9.97 1,213.92 ± 11.91 0.0189*
Total Area (mm^2) 1.77 ± 0.13 1.80 ± 0.10 0.6485