Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Nt5c1b KO Male
M
12wk
B6N(Cg)-Nt5c1b<1e.1(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Nt5c1b KO Female
F
12wk
B6N(Cg)-Nt5c1b<1e.1(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Nt5c1b WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Nt5c1b WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Nt5c1b WT Male (Mean ± SD) | Nt5c1b KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 50.60 ± 5.88 | 72.80 ± 2.97 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.00 ± 4.87 | 50.92 ± 1.35 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 22.01 ± 3.66 | 21.52 ± 3.59 | 0.8146 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.46 ± 0.48 | 8.19 ± 2.30 | <0.001* |
| Body Weight (g) | 27.49 ± 2.14 | 25.05 ± 1.49 | 0.0353* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.366 ± 0.074 | 0.638 ± 0.086 | <0.001* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.61 ± 1.37 | 11.33 ± 0.95 | 0.0045* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.60 ± 5.31 | 70.51 ± 3.34 | <0.001* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.26 ± 0.16 | 1.49 ± 0.13 | 0.0152* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 28.20 ± 3.69 | 42.80 ± 1.95 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.40 ± 5.31 | 29.49 ± 3.34 | <0.001* |
| Trabecular Number (Tb.N) (#/mm) | 2.80 ± 0.24 | 2.27 ± 0.18 | <0.001* |
| Trabecular Spacing (Tb.Sp) (µm) | 313.32 ± 30.86 | 396.72 ± 33.47 | <0.001* |
| Trabecular Thickness (Tb.Th) (µm) | 47.04 ± 2.35 | 49.94 ± 1.61 | 0.0236* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.93 ± 1.89 | 20.23 ± 3.60 | 0.0165* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 7.66 ± 0.89 | 12.83 ± 3.41 | 0.0093* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.00 ± 1.80 | 7.53 ± 1.23 | 0.5995 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 86.91 ± 3.57 | 79.74 ± 3.85 | 0.0040* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 49.00 ± 6.11 | 62.20 ± 7.87 | 0.0048* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.00 ± 6.11 | 37.80 ± 7.87 | 0.0048* |